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rdf:type |
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lifeskim:mentions |
umls-concept:C0003241,
umls-concept:C0004561,
umls-concept:C0006819,
umls-concept:C0017082,
umls-concept:C0017337,
umls-concept:C0023810,
umls-concept:C0036849,
umls-concept:C0175697,
umls-concept:C0205332,
umls-concept:C0443288,
umls-concept:C0591833,
umls-concept:C1442518,
umls-concept:C1552652,
umls-concept:C1552685,
umls-concept:C1705195,
umls-concept:C2697656,
umls-concept:C2700640
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pubmed:issue |
1-2
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pubmed:dateCreated |
2004-6-29
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pubmed:abstractText |
In Guillain-Barré syndrome following Campylobacter enteritis, anti-lipopolysaccharide antibodies cross-react with neural gangliosides, thereby precipitating autoimmune neuropathy. We examined the properties of 15 murine anti-LPS/ganglioside mAbs specific for NeuAc(alpha2-8)NeuAc-Gal disialosyl epitopes. Many mAbs displayed features of an innate B cell origin including polyreactivity (13/15), hybridoma CD5 mRNA expression (5/15), predominance of IgM (9/15) or IgG3 (3/6) isotype, low affinity, and utilisation of unmutated VH and VL VDJ rearrangements. Antibody specificity resided in highly selective V gene usage, with 6/15 mAbs being encoded by the VH7183.3b gene. These data indicate that neuropathogenic antiganglioside autoantibodies can arise from the natural autoantibody repertoire.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0165-5728
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
152
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
98-111
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15223242-Amino Acid Sequence,
pubmed-meshheading:15223242-Animals,
pubmed-meshheading:15223242-Antibodies, Monoclonal,
pubmed-meshheading:15223242-Antibody Affinity,
pubmed-meshheading:15223242-Antibody Specificity,
pubmed-meshheading:15223242-Autoantibodies,
pubmed-meshheading:15223242-B-Lymphocytes,
pubmed-meshheading:15223242-Base Sequence,
pubmed-meshheading:15223242-Campylobacter jejuni,
pubmed-meshheading:15223242-Epitopes, B-Lymphocyte,
pubmed-meshheading:15223242-Gangliosides,
pubmed-meshheading:15223242-Immunoglobulin Class Switching,
pubmed-meshheading:15223242-Immunoglobulin G,
pubmed-meshheading:15223242-Immunoglobulin M,
pubmed-meshheading:15223242-Immunoglobulin Variable Region,
pubmed-meshheading:15223242-Lipopolysaccharides,
pubmed-meshheading:15223242-Mice,
pubmed-meshheading:15223242-Molecular Sequence Data,
pubmed-meshheading:15223242-Polymerase Chain Reaction
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pubmed:year |
2004
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pubmed:articleTitle |
Innate murine B cells produce anti-disialosyl antibodies reactive with Campylobacter jejuni LPS and gangliosides that are polyreactive and encoded by a restricted set of unmutated V genes.
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pubmed:affiliation |
University Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow, Scotland G51 4TF, UK.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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