Linked Life Data

15222127

Source:http://linkedlifedata.com/resource/pubmed/id/15222127

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2004-6-29
pubmed:abstractText
A characteristic feature of heart failure is progressive deterioration of the left ventricular function. The mechanisms responsible for progression of heart failure are not known, but may be related to progressive loss of cardiomyocytes due to apoptosis or programmed cell death. Apoptosis of cardiomyocytes can cause scattered loss of cardiomyocytes and, when sufficiently widespread, this might cause heart failure. Beside cardiomyocyte apoptosis, progressive accumulation of interstitial collagen fibres in the heart occurs in the failing heart that may lead to ventricular diastolic or systolic dysfunction. Pathological processes in the failing heart (cardiomyocyte apoptosis, changes in interstitial tissue of the heart) are accompanied by an inflammatory cell response. In this paper cardiomyocyte apoptosis, inflammatory cell response and changes in interstitial tissue of the heart are reviewed as potential factors responsible for progression of the left ventricular dysfunction in heart failure.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0015-5500
pubmed:author
pubmed:issnType
Print
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
58-62
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Cytopathological basis of heart failure--cardiomyocyte apoptosis, interstitial fibrosis and inflammatory cell response.
pubmed:affiliation
Institute of Histology and Embryology, Medical Faculty, University of Ljubljana. daniel.petrovic@mf.uni-lj.si
pubmed:publicationType
Journal Article, Review