Source:http://linkedlifedata.com/resource/pubmed/id/15222107
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
2004-6-29
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pubmed:abstractText |
Ten cases of advanced and metastatic colorectal cancer treated with irinotecan plus fluorouracil and l-leucovorin systemic chemotherapy (CPT-11/5-FU/l-LV) were investigated. The 10 patients consisted of 7 males and 3 females with a mean age of 64.3 years. We diagnosed adenocarcinoma of the colon in 2 patients and of the rectum in 8 patients. Five patients had liver and lung metastases, 1 had lymph node metastases, 1 had bone marrow metastases and 3 had recurrence in a pelvic lesion. All patients underwent 3-week chemotherapy regimen (CPT-11 50 mg/m2/week + 5-FU 400 mg/m2/week + l-LV 20 mg/m2/week). Five patients received this regimen as a first-line chemotherapy and the other patients as a second-line chemotherapy after 5-FU/l-LV chemotherapy. The effect was CR or PR in all patients receiving the regimen as a first-line chemotherapy. The progression free survival time was 6.8 months and mean survival time was 10.0 months in the first-line patients. Otherwise, all second-line patients had PD. The suppression of white blood cells (grade 1 or 2) was seen in 4 patients. All patients were able to receive the systemic chemotherapy in the outpatient setting. CPT-11/5-FU/l-LV chemotherapy appears to be an effective first-line chemotherapy for advanced and metastatic colorectal cancer.
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pubmed:language |
jpn
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0385-0684
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
893-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15222107-Aged,
pubmed-meshheading:15222107-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:15222107-Camptothecin,
pubmed-meshheading:15222107-Colorectal Neoplasms,
pubmed-meshheading:15222107-Drug Administration Schedule,
pubmed-meshheading:15222107-Female,
pubmed-meshheading:15222107-Fluorouracil,
pubmed-meshheading:15222107-Humans,
pubmed-meshheading:15222107-Leucovorin,
pubmed-meshheading:15222107-Leukopenia,
pubmed-meshheading:15222107-Liver Neoplasms,
pubmed-meshheading:15222107-Lung Neoplasms,
pubmed-meshheading:15222107-Lymphatic Metastasis,
pubmed-meshheading:15222107-Male,
pubmed-meshheading:15222107-Middle Aged,
pubmed-meshheading:15222107-Retrospective Studies,
pubmed-meshheading:15222107-Treatment Outcome
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pubmed:year |
2004
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pubmed:articleTitle |
[Retrospective study of irinotecan plus fluorouracil and l-leucovorin chemotherapy for advanced and metastatic colorectal cancer].
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pubmed:affiliation |
Takeo Municipal Hospital.
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pubmed:publicationType |
Journal Article,
English Abstract
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