Source:http://linkedlifedata.com/resource/pubmed/id/15220917
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
2004-6-30
|
| pubmed:abstractText |
Kaposi sarcoma is considered a neoplasm of lymphatic endothelium infected with Kaposi sarcoma-associated herpesvirus. It is characterized by the expression of lymphatic lineage-specific genes by Kaposi sarcoma tumor cells. Here we show that infection of differentiated blood vascular endothelial cells with Kaposi sarcoma-associated herpesvirus leads to their lymphatic reprogramming; induction of approximately 70% of the main lymphatic lineage-specific genes, including PROX1, a master regulator of lymphatic development; and downregulation of blood vascular genes.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
1061-4036
|
| pubmed:author |
pubmed-author:CurryChristine LCL,
pubmed-author:DetmarMichaelM,
pubmed-author:DezubeBruce JBJ,
pubmed-author:FingerothJoyce DJD,
pubmed-author:ForemanKimberlyK,
pubmed-author:HirakawaSatoshiS,
pubmed-author:HongYoung-KwonYK,
pubmed-author:LibermannTowiaT,
pubmed-author:SageDavid RDR,
pubmed-author:ShinJay WJW
|
| pubmed:issnType |
Print
|
| pubmed:volume |
36
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
683-5
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading | |
| pubmed:year |
2004
|
| pubmed:articleTitle |
Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus.
|
| pubmed:affiliation |
Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|