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rdf:type |
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lifeskim:mentions |
umls-concept:C0000084,
umls-concept:C0006675,
umls-concept:C0015520,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0035820,
umls-concept:C0150312,
umls-concept:C1514562,
umls-concept:C1880389,
umls-concept:C1883204,
umls-concept:C1883221
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pubmed:issue |
7
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pubmed:dateCreated |
2004-6-28
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pubmed:abstractText |
Factor (F)Xa has 11 gamma-carboxylated glutamic acid (Gla) residues that are involved in calcium-dependent membrane binding. The serpin antithrombin (AT) is an important physiological regulator of FXa activity in an inhibition reaction that is enhanced by heparin. Recently, Rezaie showed that calcium further enhanced the heparin-catalyzed AT inhibition of FXa by promoting 'ternary complex' formation, and these results showed a role for the gamma-carboxyl-glutamate (Gla)-domain of FXa.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1538-7933
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1127-34
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15219196-1-Carboxyglutamic Acid,
pubmed-meshheading:15219196-Amino Acid Substitution,
pubmed-meshheading:15219196-Antithrombins,
pubmed-meshheading:15219196-Binding Sites,
pubmed-meshheading:15219196-Calcium,
pubmed-meshheading:15219196-Dose-Response Relationship, Drug,
pubmed-meshheading:15219196-Factor Xa,
pubmed-meshheading:15219196-Heparin,
pubmed-meshheading:15219196-Humans,
pubmed-meshheading:15219196-Models, Molecular,
pubmed-meshheading:15219196-Protein Binding,
pubmed-meshheading:15219196-Protein Structure, Tertiary
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pubmed:year |
2004
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pubmed:articleTitle |
Role of the gamma-carboxyglutamic acid domain of activated factor X in the presence of calcium during inhibition by antithrombin-heparin.
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pubmed:affiliation |
Department of Pathology and Laboratory Medicine, Carolina Cardiovascular Biology Center, The University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA. whinna@med.unc.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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