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rdf:type |
|
|
lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1992-10-13
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|
pubmed:abstractText |
The induction of gene mutations and chromosome aberrations by the plasmid pEJ6.6 carrying the activated c-Ha-ras-1 oncogene from human bladder carcinoma was studied in cultured Chinese hamster cells. Both an increase in the frequency of gene mutations to 6-mercaptopurine resistance and of chromosome aberrations was observed after pEJ6.6 treatment as compared to control series (pBR322). Thus the results of experiments carried out show that the pEJ6.6 plasmid possesses a mutagenic activity.
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pubmed:language |
rus
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Jun
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|
pubmed:issn |
0016-6758
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
28
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pubmed:geneSymbol |
c-Ha-ras-1
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|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
35-40
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|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1521799-6-Mercaptopurine,
pubmed-meshheading:1521799-Animals,
pubmed-meshheading:1521799-Cell Line,
pubmed-meshheading:1521799-Chromosome Aberrations,
pubmed-meshheading:1521799-Cricetinae,
pubmed-meshheading:1521799-Cricetulus,
pubmed-meshheading:1521799-Drug Resistance,
pubmed-meshheading:1521799-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:1521799-Genes, ras,
pubmed-meshheading:1521799-Humans,
pubmed-meshheading:1521799-Mutation,
pubmed-meshheading:1521799-Plasmids,
pubmed-meshheading:1521799-Urinary Bladder Neoplasms
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pubmed:year |
1992
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|
pubmed:articleTitle |
[The plasmid pEJ6.6 carrying the activated c-Ha-ras-1 oncogene increases the mutation frequency in Chinese hamster cells].
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pubmed:publicationType |
Journal Article,
English Abstract
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