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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12 Pt 1
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pubmed:dateCreated |
2004-6-25
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pubmed:abstractText |
Mesothelin is a differentiation antigen present on normal mesothelial cells and overexpressed in several human tumors, including mesothelioma and ovarian and pancreatic adenocarcinoma. The mesothelin gene encodes a precursor protein that is processed to yield the 40-kDa protein, mesothelin, attached to the cell membrane by a glycosylphosphatidyl inositol linkage and a 31-kDa shed fragment named megakaryocyte-potentiating factor. The biological function of mesothelin is not known. Mesothelin is a promising candidate for tumor-specific therapy, given its limited expression in normal tissues and high expression in several cancers. SS1(dsFv)PE38 is a recombinant anti-mesothelin immunotoxin that is undergoing clinical evaluation in patients with mesothelin-expressing tumors. There is evidence that mesothelin is an immunogenic protein and could be exploited as a therapeutic cancer vaccine. A soluble mesothelin variant has been identified and could be a useful tumor marker for malignant mesotheliomas.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3937-42
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pubmed:dateRevised |
2011-10-26
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pubmed:meshHeading |
pubmed-meshheading:15217923-Animals,
pubmed-meshheading:15217923-Antigens, Neoplasm,
pubmed-meshheading:15217923-Clinical Trials as Topic,
pubmed-meshheading:15217923-GPI-Linked Proteins,
pubmed-meshheading:15217923-Glycosylphosphatidylinositols,
pubmed-meshheading:15217923-Humans,
pubmed-meshheading:15217923-Immunohistochemistry,
pubmed-meshheading:15217923-Immunotherapy,
pubmed-meshheading:15217923-Immunotoxins,
pubmed-meshheading:15217923-Megakaryocytes,
pubmed-meshheading:15217923-Membrane Glycoproteins,
pubmed-meshheading:15217923-Mice,
pubmed-meshheading:15217923-Mice, Nude,
pubmed-meshheading:15217923-Models, Chemical,
pubmed-meshheading:15217923-Neoplasms,
pubmed-meshheading:15217923-Protein Structure, Tertiary,
pubmed-meshheading:15217923-Recombinant Proteins,
pubmed-meshheading:15217923-Tumor Markers, Biological
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pubmed:year |
2004
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pubmed:articleTitle |
Mesothelin: a new target for immunotherapy.
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pubmed:affiliation |
Laboratory of Molecular Biology, National Cancer Institute, NIH, Bethesda, Maryland, USA. hassanr@mail.nih.gov
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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