| pubmed-article:15217752 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15217752 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:15217752 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:15217752 | lifeskim:mentions | umls-concept:C0040715 | lld:lifeskim |
| pubmed-article:15217752 | lifeskim:mentions | umls-concept:C1120843 | lld:lifeskim |
| pubmed-article:15217752 | lifeskim:mentions | umls-concept:C1522702 | lld:lifeskim |
| pubmed-article:15217752 | lifeskim:mentions | umls-concept:C1334482 | lld:lifeskim |
| pubmed-article:15217752 | lifeskim:mentions | umls-concept:C0599718 | lld:lifeskim |
| pubmed-article:15217752 | lifeskim:mentions | umls-concept:C0599813 | lld:lifeskim |
| pubmed-article:15217752 | lifeskim:mentions | umls-concept:C0599893 | lld:lifeskim |
| pubmed-article:15217752 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:15217752 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:15217752 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15217752 | pubmed:dateCreated | 2004-6-25 | lld:pubmed |
| pubmed-article:15217752 | pubmed:abstractText | The signaling pathways mediating nitric oxide production and apoptosis in pancreatic beta-cells are incompletely characterized. We report here that the inhibitor of p38 MAPK (p38), SB203580 (10-100 microM) inhibits interleukin-1beta (IL-1beta)-induced nitric oxide production in rat insulin-producing RINm5F cells. SB203580 also counteracts apoptosis induced by a combination of IL-1beta and interferon-gamma. However, the contribution by p38 to the induction of inducible nitric oxide synthase (iNOS) and apoptosis is independent of NF-kappaB nuclear translocation since SB203580 does not prevent IL-1beta-induced DNA-binding of this transcription factor. Furthermore, SB203580 alone leads to phosphorylation of JNK2 which may reflect inhibition of a p38-activated phosphatase. It is concluded that p38 mediates cytokine-induced iNOS-induction and apoptosis independently of NF-kappaB translocation. Moreover, a preventive effect on iNOS induction and apoptosis by inhibition of p38 may be partly masked due to simultaneous activation of JNK2 in pancreatic RINm5F cells. | lld:pubmed |
| pubmed-article:15217752 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15217752 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15217752 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15217752 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15217752 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15217752 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15217752 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15217752 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15217752 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15217752 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15217752 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15217752 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15217752 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15217752 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15217752 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15217752 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15217752 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15217752 | pubmed:issn | 1148-5493 | lld:pubmed |
| pubmed-article:15217752 | pubmed:author | pubmed-author:WelshNilsN | lld:pubmed |
| pubmed-article:15217752 | pubmed:author | pubmed-author:SaldeenJohanJ | lld:pubmed |
| pubmed-article:15217752 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15217752 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:15217752 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15217752 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15217752 | pubmed:pagination | 47-52 | lld:pubmed |
| pubmed-article:15217752 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:15217752 | pubmed:meshHeading | pubmed-meshheading:15217752... | lld:pubmed |
| pubmed-article:15217752 | pubmed:articleTitle | p38 MAPK inhibits JNK2 and mediates cytokine-activated iNOS induction and apoptosis independently of NF-KB translocation in insulin-producing cells. | lld:pubmed |
| pubmed-article:15217752 | pubmed:affiliation | Department of Medical Cell Biology, Uppsala University, Biomedicum, PO Box 571, S-751 23 Uppsala, Sweden. Johan.Saldeen@medcellbiol.uu.se | lld:pubmed |
| pubmed-article:15217752 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15217752 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15217752 | lld:pubmed |
