|
pubmed:abstractText |
Compromised patterns of gene expression result in genomic instability, altered patterns of gene expression and tumour formation. Specifically, aberrant DNA hypermethylation in gene promoter regions leads to gene silencing, whereas global hypomethylation events can result in chromosomal instability and oncogene activation. Potential links exist between environmental agents and DNA methylation, but the destabilizing effects of environmental exposures on the DNA methylation machinery are not understood within the context of breast cancer aetiology.
|
|
pubmed:affiliation |
The London Regional Cancer Centre, Child Health Research Institute, and the Department of Biochemistry, Paediatrics and Oncology, at the University of Western Ontario, London, Ontario, Canada. bsadikov@uwo.ca
|
