Linked Life Data

15214867

Source:http://linkedlifedata.com/resource/pubmed/id/15214867

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2004-6-24
pubmed:abstractText
The expression of neuropeptide Y (NPY) and agouti-related peptide (AgRP), both of which are important neuropeptides involved in regulation of energy balance and hormone secretion, is up-regulated in the arcuate nucleus during lactation in rodents. The present study tested whether reductions in circulating insulin and/or leptin that occur in lactation provide the critical signals to these systems. Lactating female rats received 3-day infusions of either bovine insulin or recombinant rat leptin via Alzet Osmotic minipumps implanted subcutaneously in regimens designed to restore serum concentrations of these hormones to the higher non-lactating level. Compared to non-lactating rats in diestrus, lactating rats displayed significantly lower serum concentrations of insulin and leptin, and significantly increased NPY peptide concentrations in the paraventricular nucleus (PVN) and median eminence, and AgRP mRNA in the arcuate nucleus. Infusion of leptin in lactating females significantly increased serum concentrations of leptin and significantly reduced NPY concentrations in the PVN and median eminence, and decreased NPY and AgRP mRNAs in the arcuate nucleus. The same effects were produced by infusion of insulin in lactating rats, which restored both insulin and leptin concentrations in serum. The levels of pro-opiomelanocortin mRNA in the arcuate nucleus were not different in non-lactating and lactating females, and were not altered by leptin or insulin treatment. These findings support the hypothesis that the reduction in circulating leptin during lactation contributes to increased expression of NPY and AgRP in hypothalamic systems involved in the behavioural and neuroendocrine adaptations to lactation.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0953-8194
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
637-44
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:15214867-Agouti-Related Protein, pubmed-meshheading:15214867-Analysis of Variance, pubmed-meshheading:15214867-Animals, pubmed-meshheading:15214867-Arcuate Nucleus, pubmed-meshheading:15214867-Female, pubmed-meshheading:15214867-Gene Expression Regulation, pubmed-meshheading:15214867-Infusion Pumps, Implantable, pubmed-meshheading:15214867-Injections, Subcutaneous, pubmed-meshheading:15214867-Insulin, pubmed-meshheading:15214867-Intercellular Signaling Peptides and Proteins, pubmed-meshheading:15214867-Lactation, pubmed-meshheading:15214867-Leptin, pubmed-meshheading:15214867-Neuropeptide Y, pubmed-meshheading:15214867-Pro-Opiomelanocortin, pubmed-meshheading:15214867-Proteins, pubmed-meshheading:15214867-RNA, Messenger, pubmed-meshheading:15214867-Rats, pubmed-meshheading:15214867-Rats, Sprague-Dawley
pubmed:year
2004
pubmed:articleTitle
Role of leptin in orexigenic neuropeptide expression during lactation in rats.
pubmed:affiliation
Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT, USA. william.crowley@deans.pharm.utah.edu
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.