Linked Life Data

15214537

Source:http://linkedlifedata.com/resource/pubmed/id/15214537

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2004-6-24
pubmed:abstractText
Models for finding treatment plans for intensity modulated radiation therapy are usually based on a number of structure-based treatment plan evaluation criteria, which are often conflicting. Rather than formulating a model that a priori quantifies the trade-offs between these criteria, we consider a multi-criteria optimization approach that aims at finding the so-called undominated treatment plans. We present a unifying framework for studying multi-criteria optimization problems for treatment planning that establishes conditions under which treatment plan evaluation criteria can be transformed into convex criteria while preserving the set of undominated treatment plans. Such transformations are identified for many of the criteria that have been proposed to date, establishing equivalences between these criteria. In addition, it is shown that the use of a nonconvex criterion can often be avoided by transformation to an equivalent convex criterion. In particular, we show that models employing criteria such as tumour control probability, normal tissue complication probability, probability of uncomplicated tumour control, as well as sigmoidal transformations of (generalized) equivalent uniform dose are equivalent to models formulated in terms of separable voxel-based criteria that penalize dose in individual voxels.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0031-9155
pubmed:author
pubmed:issnType
Print
pubmed:day
21
pubmed:volume
49
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1991-2013
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
A unifying framework for multi-criteria fluence map optimization models.
pubmed:affiliation
Department of Industrial and Systems Engineering, University of Florida, Gainesville, Florida 32611-6595, USA. romeijn@ise.ufl.edu
pubmed:publicationType
Journal Article