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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2004-6-23
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pubmed:abstractText |
Chlamydiae have to replicate within a cytoplasmic vacuole in eukaryotic cells. Expansion of the chlamydia-laden vacuole is essential for chlamydial intravacuolar replication, which inevitably causes host cell cytoskeleton rearrangements. A cleavage fragment of keratin 8 corresponding to the central rod region was detected in the soluble fraction of chlamydia-infected cells. Since keratin 8 is a major component of the intermediate filaments in simple epithelial cells, cleavage of keratin 8 may increase the solubility of the host cell cytoskeleton and thus permit vacuole expansion in chlamydia-infected cells. A chlamydia-secreted protease designated CPAF (chlamydial protease/proteasome-like activity factor) was both necessary and sufficient for keratin 8 cleavage in chlamydia-infected cells, suggesting that chlamydiae have evolved specific mechanisms for modifying the host cell cytoskeleton.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15213128-10066459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15213128-10231006,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15213128-10377188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15213128-10679360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15213128-10790427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15213128-10845700,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15213128-10867028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15213128-11207584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15213128-11304554,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15213128-11815908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15213128-11889032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15213128-11923318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15213128-12123803,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15213128-1689541,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15213128-3121513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15213128-3903168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15213128-6208200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15213128-7511174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15213128-7539440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15213128-7542667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15213128-7684469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15213128-7854252,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15213128-8760360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15213128-8810346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15213128-8920896,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15213128-9000622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15213128-9034602,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15213128-9034603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15213128-9034607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15213128-929347,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15213128-9391117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15213128-9395922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15213128-9463399
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
72
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3863-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
2004
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pubmed:articleTitle |
Cleavage of host keratin 8 by a Chlamydia-secreted protease.
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pubmed:affiliation |
Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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