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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2005-7-19
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pubmed:abstractText |
Effect of long-term (90-100 days) exposure of rats to soluble salt of aluminum (AlCl3) on myelin lipid profile was examined. The long-term exposure to AlCl3 resulted in a 60% decrease in the total phospholipid (TPL) content while the cholesterol (CHL) content increased by 55%. Consequently the TPL/CHL molar ratio decreased significantly by 62%. The phospholipid composition of the myelin membrane changed drastically; the proportion of practically all the phospholipid classes decreased by 32 to 60% except for phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Of the latter two, proportion of PC was unchanged while PE increased in proportion by 47%. Quantitatively, all phospholipid classes decreased by from 42 to 76% with no change in the PE content. However the membrane fluidity was not altered in Al-treated rats. Many of the changes we observe here show striking similarities with the reported phospholipid profiles of Alzheimer brains.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15212698-10612066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15212698-10656181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15212698-10875436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15212698-11130287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15212698-11322172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15212698-12127022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15212698-13035283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15212698-1321237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15212698-13428781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15212698-13641241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15212698-14907713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15212698-1502515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15212698-1982955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15212698-2150771,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15212698-2328250,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15212698-2864910,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15212698-2927643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15212698-2964275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15212698-2996549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15212698-3062351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15212698-3233233,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15212698-3880616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15212698-4110051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15212698-572003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15212698-5721466,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15212698-6048776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15212698-6243693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15212698-7058341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15212698-7260077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15212698-7820573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15212698-7826343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15212698-7931272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15212698-8140621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15212698-8505021,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15212698-9130265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15212698-9476170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15212698-9500123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15212698-9518651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15212698-9522055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15212698-9580158,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15212698-9600675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15212698-963531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15212698-9677347
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pubmed:language |
eng
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pubmed:journal |
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pubmed:status |
PubMed-not-MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1476-511X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
22
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
13
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pubmed:dateRevised |
2010-9-21
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pubmed:year |
2004
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pubmed:articleTitle |
Effect of long-term aluminum feeding on lipid/phospholipid profiles of rat brain myelin.
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pubmed:affiliation |
Department of Biochemistry, Faculty of Science, M. S. University of Baroda, Vadodara, Gujarat 390 002, India. jdpandya@buffalo.edu
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pubmed:publicationType |
Journal Article
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