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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2004-6-23
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pubmed:abstractText |
Inadequate uteroplacental perfusion is one of the main reasons for recurrent spontaneous abortions (RSA). Coagulation, fibrinolysis, and vasoconstriction affect tissue perfusion. These systems are regulated by different gene products. Polymorphisms can modulate the expression levels of the respective genes and can thereby affect perfusion. Vasoconstriction is influenced by the expression of endothelial nitric oxide synthase (eNOS) and of the angiotensinogen II type 1 receptor (AT1R).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1046-7408
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
323-8
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:15212666-Abortion, Habitual,
pubmed-meshheading:15212666-Adult,
pubmed-meshheading:15212666-Case-Control Studies,
pubmed-meshheading:15212666-DNA,
pubmed-meshheading:15212666-Female,
pubmed-meshheading:15212666-Gene Frequency,
pubmed-meshheading:15212666-Genetic Predisposition to Disease,
pubmed-meshheading:15212666-Genotype,
pubmed-meshheading:15212666-Heterozygote,
pubmed-meshheading:15212666-Homozygote,
pubmed-meshheading:15212666-Humans,
pubmed-meshheading:15212666-Leukocytes,
pubmed-meshheading:15212666-Middle Aged,
pubmed-meshheading:15212666-Nitric Oxide Synthase,
pubmed-meshheading:15212666-Nitric Oxide Synthase Type III,
pubmed-meshheading:15212666-Polymerase Chain Reaction,
pubmed-meshheading:15212666-Polymorphism, Genetic,
pubmed-meshheading:15212666-Polymorphism, Single Nucleotide,
pubmed-meshheading:15212666-Pregnancy,
pubmed-meshheading:15212666-Receptor, Angiotensin, Type 2,
pubmed-meshheading:15212666-Tandem Repeat Sequences,
pubmed-meshheading:15212666-Vasoconstriction
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pubmed:year |
2004
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pubmed:articleTitle |
Vasoconstrictively acting AT1R A1166C and NOS3 4/5 polymorphisms in recurrent spontaneous abortions (RSA).
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pubmed:affiliation |
Department of Obstetrics and Gynecology - Grosshadern, Klinikum der Universität München, Germany.
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pubmed:publicationType |
Journal Article
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