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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2004-6-22
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pubmed:abstractText |
Several lines of evidence support possible serotonin transporter (5-HTT) involvement in modulating eating disorders (ED). The 5-HTT gene is a good candidate for genetic studies on the course of ED, despite controversy concerning the association between polymorphism in the 5-HTT gene promoter region (5-HTTLPR) and ED. Comparison of 5-HTTLPR distribution in 195 female Japanese ED patients and 290 age- and gender-matched control subjects facilitated examining the association between the course of the disease and 5-HTTLPR in 138 of 195 ED subjects. The 5-HTTLPR S allele frequency was significantly higher in subjects with anorexia nervosa (AN) than in control subjects. Among subjects observed > or =3 years, the S allele frequency was significantly higher in those diagnosed as AN at ED onset than in those diagnosed as AN in this study. The 5-HTTLPR S allele might play some role in the development of AN with persistent disease.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1552-4841
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2004 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
128B
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
114-7
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15211642-Adult,
pubmed-meshheading:15211642-Anorexia Nervosa,
pubmed-meshheading:15211642-Case-Control Studies,
pubmed-meshheading:15211642-Eating Disorders,
pubmed-meshheading:15211642-Female,
pubmed-meshheading:15211642-Gene Frequency,
pubmed-meshheading:15211642-Genetic Predisposition to Disease,
pubmed-meshheading:15211642-Genotype,
pubmed-meshheading:15211642-Humans,
pubmed-meshheading:15211642-Japan,
pubmed-meshheading:15211642-Membrane Glycoproteins,
pubmed-meshheading:15211642-Membrane Transport Proteins,
pubmed-meshheading:15211642-Molecular Epidemiology,
pubmed-meshheading:15211642-Nerve Tissue Proteins,
pubmed-meshheading:15211642-Polymorphism, Genetic,
pubmed-meshheading:15211642-Promoter Regions, Genetic,
pubmed-meshheading:15211642-Serotonin Plasma Membrane Transport Proteins
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pubmed:year |
2004
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pubmed:articleTitle |
Serotonin transporter regulatory region polymorphism is associated with anorexia nervosa.
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pubmed:affiliation |
National Institute on Alcoholism, Kurihama National Hospital, 5-3-1 Nobi Yokosuka, Kanagawa 239-0841, Japan.
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pubmed:publicationType |
Journal Article
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