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pubmed-article:15210595pubmed:abstractTextWe and others have reported that transient accumulation of cyclic AMP (cAMP) in the myocardium during ischemic preconditioning (IP) limits infarct size independent of protein kinase C (PKC). Accumulation of cAMP activates protein kinase A (PKA), which has been demonstrated to cause reversible inhibition of RhoA and Rho-kinase. We investigated the involvement of PKA and Rho-kinase in the infarct limitation by IP.lld:pubmed
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pubmed-article:15210595pubmed:articleTitleProtein kinase A as another mediator of ischemic preconditioning independent of protein kinase C.lld:pubmed
pubmed-article:15210595pubmed:affiliationDepartment of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Japan.lld:pubmed
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