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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2004-7-7
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pubmed:abstractText |
We and others have reported that transient accumulation of cyclic AMP (cAMP) in the myocardium during ischemic preconditioning (IP) limits infarct size independent of protein kinase C (PKC). Accumulation of cAMP activates protein kinase A (PKA), which has been demonstrated to cause reversible inhibition of RhoA and Rho-kinase. We investigated the involvement of PKA and Rho-kinase in the infarct limitation by IP.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1524-4539
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pubmed:author |
pubmed-author:AsanumaHiroshiH,
pubmed-author:FujitaMasashiM,
pubmed-author:FukushimaTomiT,
pubmed-author:HirataAkioA,
pubmed-author:HoriMasatsuguM,
pubmed-author:KitakazeMasafumiM,
pubmed-author:MinaminoTetsuoT,
pubmed-author:NodeKoichiK,
pubmed-author:OgaiAkikoA,
pubmed-author:OkudaHirokoH,
pubmed-author:SanadaShojiS,
pubmed-author:ShimokawaHiroakiH,
pubmed-author:ShinozakiYoshiroY,
pubmed-author:TakashimaSeijiS,
pubmed-author:TomoikeHitonobuH,
pubmed-author:TsukamotoOsamuO
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pubmed:issnType |
Electronic
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pubmed:day |
6
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pubmed:volume |
110
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
51-7
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15210595-Animals,
pubmed-meshheading:15210595-Cyclic AMP,
pubmed-meshheading:15210595-Cyclic AMP-Dependent Protein Kinases,
pubmed-meshheading:15210595-Dogs,
pubmed-meshheading:15210595-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:15210595-Ischemic Preconditioning, Myocardial,
pubmed-meshheading:15210595-Myocardial Infarction,
pubmed-meshheading:15210595-Protein Kinase C,
pubmed-meshheading:15210595-Protein-Serine-Threonine Kinases,
pubmed-meshheading:15210595-Receptors, Adrenergic, beta,
pubmed-meshheading:15210595-rho-Associated Kinases
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pubmed:year |
2004
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pubmed:articleTitle |
Protein kinase A as another mediator of ischemic preconditioning independent of protein kinase C.
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pubmed:affiliation |
Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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