Linked Life Data

15210505

Source:http://linkedlifedata.com/resource/pubmed/id/15210505

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2004-6-22
pubmed:abstractText
Topically applied opioids have provided effective analgesia without adverse effects, including tolerance, in adult patients with painful inflammatory conditions. The presumed mechanism of action is by interaction with opioid receptors which are sited on sensory nerve terminals and which may be up-regulated in inflammation. The use of peripherally acting opioids has not been studied in paediatric patients. The use of topical morphine gel is reported in two children with epidermolysis bullosa, where acute inflammatory pain is a major symptom and where effective analgesia is a major clinical problem. The gel provided rapid reduction in pain scores in the patients and without any reported adverse effects or tolerance. A topical route of analgesia might be extremely beneficial for children with other painful skin lesions, including burns or post-surgical wounds, and further studies are now required.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1468-2044
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
89
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
679-81
pubmed:dateRevised
2008-11-20
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Peripheral opioids in inflammatory pain.
pubmed:affiliation
Institute of Child Health, 30 Guilford Street, London WC1N 3EH, UK. G.Watterson@ich.ucl.ac.uk
pubmed:publicationType
Journal Article, Case Reports