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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
25
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pubmed:dateCreated |
2004-6-22
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pubmed:abstractText |
Peptides derived from the N- (N-HR) and C- (C-HR) terminal heptad repeat regions adjacent to the fusion peptide and transmembrane domains, respectively, of human immunodeficiency virus (HIV)-1 gp41 inhibit HIV-1 viral envelope glycoproteins (Env)-mediated cell fusion specifically. The mechanism of HIV-1 Env-mediated cell fusion and its inhibition by agents that target the N- and C-HR regions was investigated. Priming experiments with Env-expressing cells indicate that the N-HR region but not the C-HR region is exposed by treatment with sCD4 at 31 degrees C, whereas both the N- and C-HR regions are exposed at 37 degrees C.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0006-2960
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
29
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pubmed:volume |
43
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8230-3
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15209519-Amino Acid Sequence,
pubmed-meshheading:15209519-Animals,
pubmed-meshheading:15209519-Antigens, CD4,
pubmed-meshheading:15209519-CHO Cells,
pubmed-meshheading:15209519-Cell Line,
pubmed-meshheading:15209519-Cricetinae,
pubmed-meshheading:15209519-Cricetulus,
pubmed-meshheading:15209519-HIV Envelope Protein gp41,
pubmed-meshheading:15209519-HIV Fusion Inhibitors,
pubmed-meshheading:15209519-HIV-1,
pubmed-meshheading:15209519-HeLa Cells,
pubmed-meshheading:15209519-Humans,
pubmed-meshheading:15209519-Membrane Fusion,
pubmed-meshheading:15209519-Mice,
pubmed-meshheading:15209519-Molecular Sequence Data,
pubmed-meshheading:15209519-NIH 3T3 Cells,
pubmed-meshheading:15209519-Peptide Fragments,
pubmed-meshheading:15209519-Protein Structure, Secondary,
pubmed-meshheading:15209519-Receptors, CXCR4,
pubmed-meshheading:15209519-Temperature
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pubmed:year |
2004
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pubmed:articleTitle |
Temperature-dependent intermediates in HIV-1 envelope glycoprotein-mediated fusion revealed by inhibitors that target N- and C-terminal helical regions of HIV-1 gp41.
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pubmed:affiliation |
Laboratory of Experimental and Computational Biology, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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