| pubmed-article:15207642 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15207642 | lifeskim:mentions | umls-concept:C0042776 | lld:lifeskim |
| pubmed-article:15207642 | lifeskim:mentions | umls-concept:C0005768 | lld:lifeskim |
| pubmed-article:15207642 | lifeskim:mentions | umls-concept:C0013227 | lld:lifeskim |
| pubmed-article:15207642 | lifeskim:mentions | umls-concept:C0086287 | lld:lifeskim |
| pubmed-article:15207642 | lifeskim:mentions | umls-concept:C0559522 | lld:lifeskim |
| pubmed-article:15207642 | lifeskim:mentions | umls-concept:C1185740 | lld:lifeskim |
| pubmed-article:15207642 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:15207642 | lifeskim:mentions | umls-concept:C0015219 | lld:lifeskim |
| pubmed-article:15207642 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:15207642 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:15207642 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:15207642 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:15207642 | pubmed:dateCreated | 2004-6-21 | lld:pubmed |
| pubmed-article:15207642 | pubmed:abstractText | There is increasing evidence that male or female genital tract represent a distinct replication compartment for human immunodeficiency virus type 1 (HIV-1) and that such compartments may serve as a virus reservoir. Forty-four paired plasma and vaginal samples from HIV-infected females undergoing HAART were collected to examine the viral responses to antiretroviral therapy and to assess the possible role of the vaginal tract as a reservoir for drug-resistant variants. Twenty-one females had detectable viral RNA both in plasma and vaginal fluid, whereas 14 females had detectable virus only in plasma. Twelve paired samples were used to analyze HIV-1 pol sequences for the presence of drug resistance-associated mutations. Nine of the twelve paired samples exhibited discordant drug resistance mutation patterns. The other three females showed identical drug resistance-associated mutations. However, further examination of protease and RT showed numerous non-drug-associated mutations that corresponded to predefined CTL epitopes. These non-drug-associated mutations were different between plasma and vaginal viruses, suggesting that evolution of HIV-1 was independent in these two compartments. | lld:pubmed |
| pubmed-article:15207642 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15207642 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15207642 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15207642 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15207642 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15207642 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15207642 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15207642 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15207642 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15207642 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15207642 | pubmed:issn | 0042-6822 | lld:pubmed |
| pubmed-article:15207642 | pubmed:author | pubmed-author:YamamuraYY | lld:pubmed |
| pubmed-article:15207642 | pubmed:author | pubmed-author:KumarRakeshR | lld:pubmed |
| pubmed-article:15207642 | pubmed:author | pubmed-author:KumarAnilA | lld:pubmed |
| pubmed-article:15207642 | pubmed:author | pubmed-author:TiradoGrissel... | lld:pubmed |
| pubmed-article:15207642 | pubmed:author | pubmed-author:JoveGloriaG | lld:pubmed |
| pubmed-article:15207642 | pubmed:author | pubmed-author:NoelRichard... | lld:pubmed |
| pubmed-article:15207642 | pubmed:author | pubmed-author:ReyesEvelynE | lld:pubmed |
| pubmed-article:15207642 | pubmed:author | pubmed-author:SepulvedaGlad... | lld:pubmed |
| pubmed-article:15207642 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15207642 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:15207642 | pubmed:volume | 324 | lld:pubmed |
| pubmed-article:15207642 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15207642 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15207642 | pubmed:pagination | 577-86 | lld:pubmed |
| pubmed-article:15207642 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:15207642 | pubmed:meshHeading | pubmed-meshheading:15207642... | lld:pubmed |
| pubmed-article:15207642 | pubmed:meshHeading | pubmed-meshheading:15207642... | lld:pubmed |
| pubmed-article:15207642 | pubmed:meshHeading | pubmed-meshheading:15207642... | lld:pubmed |
| pubmed-article:15207642 | pubmed:meshHeading | pubmed-meshheading:15207642... | lld:pubmed |
| pubmed-article:15207642 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15207642 | pubmed:articleTitle | Differential virus evolution in blood and genital tract of HIV-infected females: evidence for the involvement of drug and non-drug resistance-associated mutations. | lld:pubmed |
| pubmed-article:15207642 | pubmed:affiliation | Laboratory of Viral Immunology, Ponce School of Medicine, Ponce 00732, Puerto Rico. | lld:pubmed |
| pubmed-article:15207642 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15207642 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15207642 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15207642 | lld:pubmed |
