Source:http://linkedlifedata.com/resource/pubmed/id/15207642
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2004-6-21
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| pubmed:abstractText |
There is increasing evidence that male or female genital tract represent a distinct replication compartment for human immunodeficiency virus type 1 (HIV-1) and that such compartments may serve as a virus reservoir. Forty-four paired plasma and vaginal samples from HIV-infected females undergoing HAART were collected to examine the viral responses to antiretroviral therapy and to assess the possible role of the vaginal tract as a reservoir for drug-resistant variants. Twenty-one females had detectable viral RNA both in plasma and vaginal fluid, whereas 14 females had detectable virus only in plasma. Twelve paired samples were used to analyze HIV-1 pol sequences for the presence of drug resistance-associated mutations. Nine of the twelve paired samples exhibited discordant drug resistance mutation patterns. The other three females showed identical drug resistance-associated mutations. However, further examination of protease and RT showed numerous non-drug-associated mutations that corresponded to predefined CTL epitopes. These non-drug-associated mutations were different between plasma and vaginal viruses, suggesting that evolution of HIV-1 was independent in these two compartments.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0042-6822
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
324
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
577-86
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:15207642-Adult,
pubmed-meshheading:15207642-Amino Acid Sequence,
pubmed-meshheading:15207642-Anti-HIV Agents,
pubmed-meshheading:15207642-Antiretroviral Therapy, Highly Active,
pubmed-meshheading:15207642-Disease Transmission, Infectious,
pubmed-meshheading:15207642-Drug Resistance, Viral,
pubmed-meshheading:15207642-Female,
pubmed-meshheading:15207642-Genes, pol,
pubmed-meshheading:15207642-HIV Infections,
pubmed-meshheading:15207642-HIV Protease,
pubmed-meshheading:15207642-HIV Reverse Transcriptase,
pubmed-meshheading:15207642-HIV-1,
pubmed-meshheading:15207642-Humans,
pubmed-meshheading:15207642-Infectious Disease Transmission, Vertical,
pubmed-meshheading:15207642-Molecular Sequence Data,
pubmed-meshheading:15207642-Mutation,
pubmed-meshheading:15207642-RNA, Viral,
pubmed-meshheading:15207642-Sequence Alignment,
pubmed-meshheading:15207642-Vagina
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Differential virus evolution in blood and genital tract of HIV-infected females: evidence for the involvement of drug and non-drug resistance-associated mutations.
|
| pubmed:affiliation |
Laboratory of Viral Immunology, Ponce School of Medicine, Ponce 00732, Puerto Rico.
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
|