Linked Life Data

15207370

Source:http://linkedlifedata.com/resource/pubmed/id/15207370

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2004-6-21
pubmed:abstractText
The effect of SO2 derivatives, a common air pollutant and exists in vivo as an equilibrium between bisulfate and sulfite, on transient outward currents (TOCS) in hippocampal neurons were studied using the whole cell configuration of patch-clamp technique. TOCS that preliminary included a fast inactivating (A-current or IA) and a slow inactivating (D-current or ID ) current, were isolated based on the kinetics and pharmacological properties in the presence of 50 mM TEA. The results showed that SO2 derivatives reversibly increased the amplitudes of TOCS in a concentration dependent and voltage dependent. Half-increase dose on TOCS was 25 microM. In vivo, SO2 derivatives shifted the steady-state inactivation curve of TOCS in the depolarizing direction but had little effect on the activation curve. Half-maximal inactivation voltage of TOCS was -69.6+/-1.0 mV before and -56.8+/-0.4 mV after application of 10 microM SO2 derivatives. SO2 derivatives increased the maximal conductance and delayed the inactivation process of TOCS. These results suggest that SO2 derivatives would increase the excitability of hippocampal neurons.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0278-6915
pubmed:author
pubmed:issnType
Print
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1211-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Effects of derivatives of sulfur dioxide on transient outward potassium currents in acutely isolated hippocampal neurons.
pubmed:affiliation
Institute of Environmental Medicine and Toxicology, Shanxi University, Taiyuan 030006, PR China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't