|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0002600,
umls-concept:C0017337,
umls-concept:C0028420,
umls-concept:C0057223,
umls-concept:C0086045,
umls-concept:C0178602,
umls-concept:C0205103,
umls-concept:C0205231,
umls-concept:C0205245,
umls-concept:C0392747,
umls-concept:C0681842,
umls-concept:C0683149,
umls-concept:C1332828,
umls-concept:C1332830
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|
pubmed:issue |
9
|
|
pubmed:dateCreated |
2004-8-27
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|
pubmed:abstractText |
Recently, new polymorphisms were described in connection with intermediate and ultrarapid CYP2D6 metabolism. These may allow a much desired prediction of metabolic activity within the extensive metabolizer group. The functional consequences are still being discussed with few data available for clinical patients.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
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pubmed:month |
Sep
|
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pubmed:issn |
0009-9147
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
50
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1623-33
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pubmed:dateRevised |
2006-4-27
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pubmed:meshHeading |
pubmed-meshheading:15205367-Adult,
pubmed-meshheading:15205367-Aged,
pubmed-meshheading:15205367-Alleles,
pubmed-meshheading:15205367-Amitriptyline,
pubmed-meshheading:15205367-Antidepressive Agents, Tricyclic,
pubmed-meshheading:15205367-Aryl Hydrocarbon Hydroxylases,
pubmed-meshheading:15205367-Cytochrome P-450 CYP2D6,
pubmed-meshheading:15205367-DNA,
pubmed-meshheading:15205367-Depression,
pubmed-meshheading:15205367-Female,
pubmed-meshheading:15205367-Genotype,
pubmed-meshheading:15205367-Humans,
pubmed-meshheading:15205367-Male,
pubmed-meshheading:15205367-Middle Aged,
pubmed-meshheading:15205367-Mixed Function Oxygenases,
pubmed-meshheading:15205367-Nortriptyline,
pubmed-meshheading:15205367-Pharmacogenetics,
pubmed-meshheading:15205367-Polymerase Chain Reaction,
pubmed-meshheading:15205367-Prospective Studies,
pubmed-meshheading:15205367-Statistics, Nonparametric
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pubmed:year |
2004
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pubmed:articleTitle |
Allele-specific change of concentration and functional gene dose for the prediction of steady-state serum concentrations of amitriptyline and nortriptyline in CYP2C19 and CYP2D6 extensive and intermediate metabolizers.
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pubmed:affiliation |
Institut für Klinische Chemie und Pathobiochemie, Technische Universität München, Munich, Germany. Steimer@KlinChem.med.TU-Muenchen.de
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pubmed:publicationType |
Journal Article,
Multicenter Study
|
