Linked Life Data

15203170

Source:http://linkedlifedata.com/resource/pubmed/id/15203170

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
14
pubmed:dateCreated
2004-6-18
pubmed:abstractText
A series of molecules with dual inhibitory activities on calpain and lipid peroxidation were synthesized. These hybrid compounds were built on the calpain pharmacophore 2-hydroxytetrahydrofuran linked to a set of antioxidants via a l-leucine linker. Compound 7, the most potent in cellular calpain and lipid peroxidation inhibitions, provided effective protection against glial cell death induced by maitotoxin.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0960-894X
pubmed:author
pubmed:issnType
Print
pubmed:day
16
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3825-8
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Novel dual inhibitors of calpain and lipid peroxidation.
pubmed:affiliation
Department of Medicinal Chemistry, Ipsen Research Laboratories, Institut Henri Beaufour, 5, Avenue du Canada, 91966 Les Ulis Cedex, France. serge.auvin@ipsen.com
pubmed:publicationType
Journal Article