|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0014898,
umls-concept:C0034830,
umls-concept:C0066393,
umls-concept:C0220781,
umls-concept:C0243071,
umls-concept:C0243076,
umls-concept:C0392747,
umls-concept:C0441655,
umls-concept:C0678594,
umls-concept:C1260969,
umls-concept:C1554963,
umls-concept:C1883254,
umls-concept:C2603343
|
|
pubmed:issue |
14
|
|
pubmed:dateCreated |
2004-6-18
|
|
pubmed:abstractText |
The development of novel agents for the differentiation of neuronal nicotinic acetylcholine receptors (nAChRs) is important for the treatment of a variety of pathological conditions. We have prepared and evaluated a number of simpler analogues of the norditerpeniod alkaloid methyllycaconitine (MLA) in an effort to understand molecular determinants of nAChR*small molecule interactions. We have previously reported the synthesis and evaluation of a series of ring E analogues of MLA. We report here the optimization of the alpha3beta4* functional activity of this series of compounds through modification of the ester.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0960-894X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
16
|
|
pubmed:volume |
14
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
3739-42
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:15203153-Aconitine,
pubmed-meshheading:15203153-Alkaloids,
pubmed-meshheading:15203153-Animals,
pubmed-meshheading:15203153-Binding, Competitive,
pubmed-meshheading:15203153-Catecholamines,
pubmed-meshheading:15203153-Cell Line,
pubmed-meshheading:15203153-Diterpenes,
pubmed-meshheading:15203153-Esters,
pubmed-meshheading:15203153-Nicotinic Antagonists,
pubmed-meshheading:15203153-Receptors, Nicotinic,
pubmed-meshheading:15203153-Structure-Activity Relationship
|
|
pubmed:year |
2004
|
|
pubmed:articleTitle |
Structure activity studies of ring E analogues of methyllycaconitine. Part 2: Synthesis of antagonists to the alpha3beta4* nicotinic acetylcholine receptors through modifications to the ester.
|
|
pubmed:affiliation |
Department of Chemistry and Biochemistry, Ohio University, Athens, OH 45701, USA. bergmeis@ohio.edu
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
