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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
14
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pubmed:dateCreated |
2004-6-18
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pubmed:abstractText |
This paper describes the synthesis of several novel T-type calcium channel antagonists that inhibit calcium influx into the cell, which in turn regulates unknown aspects of the cell cycle pathway that are responsible for cellular proliferation. A library of compounds was synthesized and a brief structure activity relationship will be described. From these studies we have identified a compound (1) that displays anti-proliferative activity in the low micromolar range across a variety of cancer cell lines.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3691-5
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15203145-Animals,
pubmed-meshheading:15203145-Antineoplastic Agents,
pubmed-meshheading:15203145-Bepridil,
pubmed-meshheading:15203145-Calcium Channel Blockers,
pubmed-meshheading:15203145-Calcium Channels, T-Type,
pubmed-meshheading:15203145-Cell Division,
pubmed-meshheading:15203145-Drug Design,
pubmed-meshheading:15203145-Evaluation Studies as Topic,
pubmed-meshheading:15203145-Humans,
pubmed-meshheading:15203145-Inhibitory Concentration 50,
pubmed-meshheading:15203145-Jurkat Cells,
pubmed-meshheading:15203145-Perhexiline,
pubmed-meshheading:15203145-Structure-Activity Relationship,
pubmed-meshheading:15203145-Tumor Cells, Cultured
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pubmed:year |
2004
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pubmed:articleTitle |
Design, synthesis, and biological evaluation of novel T-Type calcium channel antagonists.
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pubmed:affiliation |
Department of Chemistry, University of Virginia, Charlottesville, VA 22904-4319, USA. wfm3s@virginia.edu
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pubmed:publicationType |
Journal Article
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