Linked Life Data

15203135

Source:http://linkedlifedata.com/resource/pubmed/id/15203135

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SubjectPredicateObjectContext
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pubmed-article:15203135pubmed:abstractTextThe high lipophilicity of a series of cytosolic phospholipase A(2) inhibitors has been reduced by the modification of a decyloxyphenyl chain designed to mimic the arachidonyl group of the natural substrate. These changes have resulted in an improvement in the whole cell potency of the inhibitors.lld:pubmed
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pubmed-article:15203135pubmed:articleTitleSynthesis and evaluation of substrate-mimicking cytosolic phospholipase A2 inhibitors--reducing the lipophilicity of the arachidonyl chain isostere.lld:pubmed
pubmed-article:15203135pubmed:affiliationDepartments of Medicinal Chemistry, Molecular Biology, and Discovery BioScience, AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, Leicestershire LE11 5RH, United Kingdom. iain.walters@astrazeneca.comlld:pubmed
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