Linked Life Data

15201955

Source:http://linkedlifedata.com/resource/pubmed/id/15201955

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2004-6-17
pubmed:abstractText
In the current study, we compared the differential expression profiles of genes affected by endocrine disruptor in gastric carcinomas of the young and old using cDNA microarray. Five gastric carcinoma tissues of young patients (< or =35 years) were compared with 5 disease-free gastric tissues of age-matched healthy young people (experiment 1) and 5 gastric carcinoma tissues of old patients (> or =65 years) (experiment 2), respectively. We hybridized the tissues with IntelliGene Human DNA Chip for endocrine disruption study, and identified finally the results common to the two experiments. Of the 220 genes represented on the array, 6 genes were up-regulated and 3 genes were down-regulated in the gastric carcinomas of young patients compared with those of old patients and those of the young volunteers. In conclusion, the genes affected by endocrine disruptors were differently expressed in young-age gastric carcinoma versus the old-age gastric carcinoma. So, we suggest that the gastric carcinoma in the young is the result of a genetic background that differs from that of the old and endocrine disruptors may play an important role in the carcinogenesis of gastric carcinoma in the young.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1021-335X
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
33-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Differences in genetic expression profiles between young-age and old-age gastric adenocarcinoma using cDNA microarray for endocrine disruptor study.
pubmed:affiliation
Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't