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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2004-6-17
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pubmed:abstractText |
The molecular identification and characterization of the adenosine triphosphate (ATP)-sensitive family of P2 receptors is comparatively new. There are two main subgroups, each with several subtypes and widespread tissue distribution, including the kidney. A unique member of the P2X subgroup of P2 receptors is the ATP-gated ion channel P2X(7), which on activation can cause cell blebbing, cytokine release, and cell death by necrosis or apoptosis. We report expression of this receptor in normal rat kidney and in two chronic models of glomerular injury: streptozotocin-induced (STZ) diabetes and ren-2 transgenic (TGR) hypertension.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Triphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/P2rx7 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/P2rx7 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Purinergic P2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Purinergic P2X7,
http://linkedlifedata.com/resource/pubmed/chemical/Ren2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Renin
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0085-2538
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
66
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
157-66
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15200422-Adenosine Triphosphate,
pubmed-meshheading:15200422-Animals,
pubmed-meshheading:15200422-Animals, Genetically Modified,
pubmed-meshheading:15200422-Blotting, Western,
pubmed-meshheading:15200422-Chronic Disease,
pubmed-meshheading:15200422-Diabetes Mellitus, Experimental,
pubmed-meshheading:15200422-Hypertension,
pubmed-meshheading:15200422-Immunohistochemistry,
pubmed-meshheading:15200422-In Situ Nick-End Labeling,
pubmed-meshheading:15200422-Kidney Glomerulus,
pubmed-meshheading:15200422-Male,
pubmed-meshheading:15200422-Microscopy, Immunoelectron,
pubmed-meshheading:15200422-Rats,
pubmed-meshheading:15200422-Rats, Sprague-Dawley,
pubmed-meshheading:15200422-Receptors, Purinergic P2,
pubmed-meshheading:15200422-Receptors, Purinergic P2X7,
pubmed-meshheading:15200422-Renin,
pubmed-meshheading:15200422-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15200422-Staining and Labeling,
pubmed-meshheading:15200422-Tissue Distribution
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pubmed:year |
2004
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pubmed:articleTitle |
Glomerular expression of the ATP-sensitive P2X receptor in diabetic and hypertensive rat models.
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pubmed:affiliation |
Centre for Nephrology and Department of Physiology, Royal Free and University College Medical School, University College London, London, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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