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pubmed-article:15200341pubmed:abstractText[reaction: see text] L-Proline-based small peptides have been developed as efficient catalysts for the asymmetric direct aldol reactions of hydroxyacetone with aldehydes. Chiral 1,4-diols 7, which are disfavored products in similar aldol reactions catalyzed by either aldolases or L-proline, were obtained in high yields and enantioselectivities of up to 96% ee with peptides 3 and 4 in aqueous media.lld:pubmed
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pubmed-article:15200341pubmed:authorpubmed-author:GongLiu-ZhuLZlld:pubmed
pubmed-article:15200341pubmed:authorpubmed-author:MiAi-QiaoAQlld:pubmed
pubmed-article:15200341pubmed:authorpubmed-author:JiangYao-Zhon...lld:pubmed
pubmed-article:15200341pubmed:authorpubmed-author:YangZhi-HuaZHlld:pubmed
pubmed-article:15200341pubmed:authorpubmed-author:TangZhuoZlld:pubmed
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pubmed-article:15200341pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:15200341pubmed:articleTitleSmall peptides catalyze highly enantioselective direct aldol reactions of aldehydes with hydroxyacetone: unprecedented regiocontrol in aqueous media.lld:pubmed
pubmed-article:15200341pubmed:affiliationKey Laboratory for Asymmetric Synthesis and Chirotechnology of Sichuan Province and Union Laboratory of Asymmetric Synthesis, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041, China.lld:pubmed
pubmed-article:15200341pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15200341pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed