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rdf:type |
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lifeskim:mentions |
umls-concept:C0001992,
umls-concept:C0030956,
umls-concept:C0050452,
umls-concept:C0162867,
umls-concept:C0205250,
umls-concept:C0439851,
umls-concept:C0443286,
umls-concept:C0599956,
umls-concept:C0761982,
umls-concept:C1552596,
umls-concept:C1947931
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pubmed:issue |
13
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pubmed:dateCreated |
2004-6-17
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pubmed:abstractText |
[reaction: see text] L-Proline-based small peptides have been developed as efficient catalysts for the asymmetric direct aldol reactions of hydroxyacetone with aldehydes. Chiral 1,4-diols 7, which are disfavored products in similar aldol reactions catalyzed by either aldolases or L-proline, were obtained in high yields and enantioselectivities of up to 96% ee with peptides 3 and 4 in aqueous media.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1523-7060
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
24
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
|
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pubmed:pagination |
2285-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
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pubmed:year |
2004
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pubmed:articleTitle |
Small peptides catalyze highly enantioselective direct aldol reactions of aldehydes with hydroxyacetone: unprecedented regiocontrol in aqueous media.
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|
pubmed:affiliation |
Key Laboratory for Asymmetric Synthesis and Chirotechnology of Sichuan Province and Union Laboratory of Asymmetric Synthesis, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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