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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2004-7-14
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pubmed:abstractText |
Parathyroid hormone-related protein (PTHrP) is a key factor in the development of bone metastases, which are a major barrier in treating prostate cancer patients. In this study, we attempted to identify PTHrP-derived peptides immunogenic in human histocompatibility leukocyte antigen (HLA)-A24(+) prostate cancer patients. Among four different PTHrP peptides carrying the HLA-A24 binding motif, both the PTHrP(36-44) and PTHrP(102-111) peptides efficiently induced peptide-specific cytotoxic T lymphocytes from peripheral blood mononuclear cells (PBMCs) of HLA-A24(+) prostate cancer patients. Peptide-stimulated PBMCs showed cytotoxicity against prostate cancer cells in an HLA-A24-restricted manner. Experiments using antibodies and cold inhibition targets confirmed that their cytotoxicity was dependent on PTHrP peptide-specific and CD8(+) T cells. Immunoglobulin G reactive to the PTHrP(102-111) or PTHrP(110-119) peptide was frequently detected in the plasma of prostate cancer patients, suggesting that the PTHrP(102-111) peptide is able to elicit cellular and humoral immune responses in cancer patients. These results indicate that the PTHrP could be a promising target molecule for specific immunotherapy of HLA-A24(+) prostate cancer patients with metastases.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15199397-10204484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15199397-10735013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15199397-11099318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15199397-11315507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15199397-11547122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15199397-11870627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15199397-12012109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15199397-12135424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15199397-12242725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15199397-12391194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15199397-12824881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15199397-12841872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15199397-12843798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15199397-12886526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15199397-12949939,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15199397-12967479,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15199397-14634796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15199397-14676634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15199397-14764741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15199397-14871969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15199397-1658941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15199397-3616618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15199397-7890324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15199397-8213933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15199397-8254189,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15199397-8592727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15199397-8977634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15199397-9362424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15199397-9500606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15199397-9500607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15199397-9650914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15199397-9935203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15199397-9973112
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0007-0920
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
91
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
287-96
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:15199397-CD8-Positive T-Lymphocytes,
pubmed-meshheading:15199397-Case-Control Studies,
pubmed-meshheading:15199397-Cell Survival,
pubmed-meshheading:15199397-HLA-A Antigens,
pubmed-meshheading:15199397-HLA-A24 Antigen,
pubmed-meshheading:15199397-Humans,
pubmed-meshheading:15199397-Immunoglobulin G,
pubmed-meshheading:15199397-Interferon-gamma,
pubmed-meshheading:15199397-Male,
pubmed-meshheading:15199397-Parathyroid Hormone-Related Protein,
pubmed-meshheading:15199397-Peptide Fragments,
pubmed-meshheading:15199397-Prostate,
pubmed-meshheading:15199397-Prostatic Neoplasms,
pubmed-meshheading:15199397-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:15199397-Tumor Cells, Cultured
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pubmed:year |
2004
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pubmed:articleTitle |
Identification of parathyroid hormone-related protein-derived peptides immunogenic in human histocompatibility leukocyte antigen-A24+ prostate cancer patients.
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pubmed:affiliation |
Department of Immunology, Kurume University School of Medicine, Fukuoka, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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