Source:http://linkedlifedata.com/resource/pubmed/id/15197537
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
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| pubmed:dateCreated |
2004-8-18
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| pubmed:abstractText |
N-acetyltransferase 1 (NAT1) modifies bladder cancer risk in European populations exposed to aromatic amines in cigarette smoke. The present study was performed to investigate a possible association between NAT1*10 and NAT1*14A genotypes and bladder cancer risk in benzidine-exposed Chinese workers. Based on the cytological gradings of exfoliated urothelial cells according to Papanicolaou, an exposed research cohort was stratified into subgroups. An allele-specific PCR-based procedure was used to detect the polymorphism in the polyadenylation signal at the locus NAT1 T(1088)A. A nested PCR-RFLP procedure was conducted to differentiate NAT1*14A (T(1088)A, C(1095)A, and G(560)A) from NAT1*10 (T(1088)A, C(1095)A). No significantly different frequencies of homozygous and heterozygous NAT1*10 alleles were found among the subgroups with (i) gradings according to Papanicolaou < or = II (18.3 and 40.2%, respectively), (ii) higher gradings according to Papanicolaou (> II; 28.0 and 34.1%, respectively), and (iii) with bladder cancer (26.3 and 34.2%, respectively). The present data show that NAT1*10 neither displayed an association with an elevated grading of urothelial cells nor a clear impact on the risk for bladder cancer in benzidine-exposed Chinese workers. Discrepancies with the findings in European populations could point to ethnic differences in the disposition of aromatic amines.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Arylamine N-Acetyltransferase,
http://linkedlifedata.com/resource/pubmed/chemical/Benzidines,
http://linkedlifedata.com/resource/pubmed/chemical/Carcinogens,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/N-acetyltransferase 1
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| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
0340-5761
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
78
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
425-9
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:15197537-Adult,
pubmed-meshheading:15197537-Arylamine N-Acetyltransferase,
pubmed-meshheading:15197537-Benzidines,
pubmed-meshheading:15197537-Carcinogens,
pubmed-meshheading:15197537-Carcinoma, Transitional Cell,
pubmed-meshheading:15197537-China,
pubmed-meshheading:15197537-DNA, Neoplasm,
pubmed-meshheading:15197537-Ethnic Groups,
pubmed-meshheading:15197537-Female,
pubmed-meshheading:15197537-Gene Frequency,
pubmed-meshheading:15197537-Genotype,
pubmed-meshheading:15197537-Humans,
pubmed-meshheading:15197537-Isoenzymes,
pubmed-meshheading:15197537-Male,
pubmed-meshheading:15197537-Occupational Exposure,
pubmed-meshheading:15197537-Polymorphism, Genetic,
pubmed-meshheading:15197537-Smoking,
pubmed-meshheading:15197537-Urinary Bladder Neoplasms,
pubmed-meshheading:15197537-Urothelium,
pubmed-meshheading:15197537-Vaginal Smears
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| pubmed:year |
2004
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| pubmed:articleTitle |
Polymorphism in the N-acetyltransferase 1 alleles NAT1*10 and NAT1*14A and cytological gradings of exfoliated urothelial cells in benzidine-exposed Chinese workers: discussion of ethnic differences.
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| pubmed:affiliation |
Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 225 Chongqing Rd. (S.), 200025 Shanghai, China.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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