Source:http://linkedlifedata.com/resource/pubmed/id/15195255
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2004-6-14
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pubmed:abstractText |
High levels of human immunodeficiency virus (HIV) in rectal secretions and semen likely increase the risk of HIV transmission. HIV-infected men who have sex with men made 2-3 study visits, over 4 weeks, to assess rectal, seminal, and plasma levels of HIV RNA. Mixed-effects models estimated the effect of factors on HIV shedding. Twenty-seven (42%) of 64 men were receiving antiretroviral therapy (ART); regardless of ART use, median HIV RNA levels were higher in rectal secretions (4.96 log(10) copies/mL) than in blood plasma (4.24 log(10) copies/mL) or seminal plasma (3.55 log(10) copies/mL; P<.05, each comparison). ART was associated with a 1.3-log(10) reduction in rectal HIV RNA in a model without plasma HIV RNA; with and without plasma RNA in models, ART accounted for a >1-log(10) decrease in seminal HIV RNA levels. Thus, controlling for plasma HIV RNA, ART had an independent effect on seminal, but not rectal, HIV levels.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-1899
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
190
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
156-61
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15195255-Adult,
pubmed-meshheading:15195255-Anti-HIV Agents,
pubmed-meshheading:15195255-HIV Infections,
pubmed-meshheading:15195255-HIV-1,
pubmed-meshheading:15195255-Homosexuality,
pubmed-meshheading:15195255-Humans,
pubmed-meshheading:15195255-Male,
pubmed-meshheading:15195255-Middle Aged,
pubmed-meshheading:15195255-Mucous Membrane,
pubmed-meshheading:15195255-RNA, Viral,
pubmed-meshheading:15195255-Rectum,
pubmed-meshheading:15195255-Semen
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pubmed:year |
2004
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pubmed:articleTitle |
Higher concentration of HIV RNA in rectal mucosa secretions than in blood and seminal plasma, among men who have sex with men, independent of antiretroviral therapy.
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pubmed:affiliation |
Department of Medicine, University of Washington, Seattle 98104, USA. zuckermn@u.washington.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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