Linked Life Data

15194878

Source:http://linkedlifedata.com/resource/pubmed/id/15194878

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2004-6-14
pubmed:abstractText
The present study was designed to examine the ventral tegmental area (VTA) dopamine neuronal activity in nicotine withdrawal rats by means of in vivo single-unit extracellular recordings. Animals were treated with nicotine base (6 mg/kg/day, s.c.) four times daily for 12 days. One day after the last nicotine administration, the firing rates of the VTA dopamine neurons were found to be significantly decreased. Following 2, 3, 5 and 10 days of nicotine withdrawal, however, the firing rates returned to the control levels. The number of spontaneously active dopamine cells was not altered at any time points. The results indicate that the VTA dopamine neuronal activity is reduced during the first day of nicotine withdrawal.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0959-4965
pubmed:author
pubmed:issnType
Print
pubmed:day
28
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1479-81
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Decrease of ventral tegmental area dopamine neuronal activity in nicotine withdrawal rats.
pubmed:affiliation
Department of Pharmacology, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China.
pubmed:publicationType
Journal Article