|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2004-6-14
|
|
pubmed:abstractText |
To explore the relation of the MMP-1 1G/2G and MMP-3 5A/6A promoter polymorphisms with head and neck squamous cell carcinoma (HNSCC), DNA specimens extracted from peripheral blood cells of HNSCC patients and healthy controls were genotyped. The frequency of the MMP-1 2G/2G genotype was significantly higher in HNSCC patients (n = 140) than in age- and sex-matched controls (n = 223) (P = 0.042; OR, 1.56). In the MMP-3 polymorphism, there was no significant difference in the genotype distribution between patients and controls. These data suggest that the MMP-1 promoter polymorphism may be associated with HNSCC.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0304-3835
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
Copyright 2004 Elsevier Ireland Ltd.
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
28
|
|
pubmed:volume |
211
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
19-24
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:15194213-Adult,
pubmed-meshheading:15194213-Age Factors,
pubmed-meshheading:15194213-Aged,
pubmed-meshheading:15194213-Carcinoma, Squamous Cell,
pubmed-meshheading:15194213-Female,
pubmed-meshheading:15194213-Head and Neck Neoplasms,
pubmed-meshheading:15194213-Humans,
pubmed-meshheading:15194213-Male,
pubmed-meshheading:15194213-Matrix Metalloproteinase 1,
pubmed-meshheading:15194213-Matrix Metalloproteinase 3,
pubmed-meshheading:15194213-Middle Aged,
pubmed-meshheading:15194213-Polymorphism, Genetic,
pubmed-meshheading:15194213-Promoter Regions, Genetic
|
|
pubmed:year |
2004
|
|
pubmed:articleTitle |
Association of matrix metalloproteinase (MMP)-1 promoter polymorphism with head and neck squamous cell carcinoma.
|
|
pubmed:affiliation |
Department of Otolaryngology, Yamaguchi University School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi, 755-8505, Japan.
|
|
pubmed:publicationType |
Journal Article
|
