Linked Life Data

15193882

Source:http://linkedlifedata.com/resource/pubmed/id/15193882

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2004-6-14
pubmed:abstractText
Bone morphogenetic proteins (BMPs) are biologically active molecules capable of inducing new bone formation, and show potential for clinical use in bone defect repair. However, an ideal system for delivering BMPs that can potentiate their bone-inducing ability and provide initial mechanical strength and scaffold for bone ingrowth has not yet been developed. In this study, to construct a carrier/scaffold system for BMPs, we combined two biomaterials: interconnected-porous calcium hydroxyapatite ceramics (IP-CHA), and the synthetic biodegradable polymer poly D,L,-lactic acid-polyethyleneglycol block co-polymer (PLA-PEG). We used a rabbit radii model to evaluate the bone-regenerating efficacy of rhBMP-2/PLA-PEG/IP-CHA composite. At 8 weeks after implantation, all bone defects in groups treated with 5 or 20 microg of BMP were completely repaired with sufficient strength. Furthermore, using this carrier scaffold system, we reduced the amount of BMP necessary for such results to about a tenth of the amount needed in previous studies, probably due to the superior osteoconduction ability of IP-CHA and the optimal drug delivery system provided by PLA-PEG, inducing new bone formation in the interconnected pores. The present findings indicate that the synthetic biodegradable polymer/IP-CHA composite is an excellent combination carrier/scaffold delivery system for rhBMP-2, and that it strongly promotes the clinical effects of rhBMP-2 in bone tissue regeneration.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0142-9612
pubmed:author
pubmed:copyrightInfo
Copyright 2004 Elsevier Ltd.
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
73-9
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:15193882-Animals, pubmed-meshheading:15193882-Bone Morphogenetic Protein 2, pubmed-meshheading:15193882-Bone Morphogenetic Proteins, pubmed-meshheading:15193882-Bone Regeneration, pubmed-meshheading:15193882-Bone Substitutes, pubmed-meshheading:15193882-Dose-Response Relationship, Drug, pubmed-meshheading:15193882-Drug Carriers, pubmed-meshheading:15193882-Drug Delivery Systems, pubmed-meshheading:15193882-Drug Implants, pubmed-meshheading:15193882-Fracture Healing, pubmed-meshheading:15193882-Hydroxyapatites, pubmed-meshheading:15193882-Lactates, pubmed-meshheading:15193882-Polyethylene Glycols, pubmed-meshheading:15193882-Rabbits, pubmed-meshheading:15193882-Radius Fractures, pubmed-meshheading:15193882-Tissue Engineering, pubmed-meshheading:15193882-Transforming Growth Factor beta, pubmed-meshheading:15193882-Treatment Outcome
pubmed:year
2005
pubmed:articleTitle
Potentiation of the activity of bone morphogenetic protein-2 in bone regeneration by a PLA-PEG/hydroxyapatite composite.
pubmed:affiliation
Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. t-kaito@let.eonet.ne.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't