Linked Life Data

15193627

Source:http://linkedlifedata.com/resource/pubmed/id/15193627

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2004-6-14
pubmed:abstractText
The relationship between neural activity and accompanying changes in cerebral blood flow (CBF) and oxygenation must be fully understood before data from brain imaging techniques can be correctly interpreted. Whether signals in fMRI reflect the neural input or output of an activated region is still unclear. Similarly, quantitative relationships between neural activity and changes in CBF are not well understood. The present study addresses these issues by using simultaneous laser Doppler flowmetry (LDF) to measure CBF and multichannel electrophysiology to record neural activity in the form of field potentials and multiunit spiking. We demonstrate that CBF-activation coupling is a nonlinear inverse sigmoid function. Comparing the data with previous work suggests that within a cortical model, CBF shows greatest spatial correlation with a current sink 500 microm below the surface corresponding to sensory input. These results show that care must be exercised when interpreting imaging data elicited by particularly strong or weak stimuli and that hemodynamic changes may better reflect the input to a region rather than its spiking output.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1053-8119
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
956-65
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Nonlinear coupling of neural activity and CBF in rodent barrel cortex.
pubmed:affiliation
Neural Imaging Research Unit, Department of Psychology, University of Sheffield, Western Bank, Sheffield S10 2TP, UK. m.jones@sheffield.ac.uk
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't