Linked Life Data

15193622

Source:http://linkedlifedata.com/resource/pubmed/id/15193622

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2004-6-14
pubmed:abstractText
The present study used functional and structural MRI to investigate differences in neuronal substrates underlying shifts of attention in young and old subjects, studied with dichotic listening. Two different consonant-vowel syllables were presented and the subjects were instructed to attend to and report from either the left or right ear stimulus. Typically, a right-ear advantage is observed when attending to the right-ear stimulus, and a left-ear advantage when attending to the left-ear stimulus. The behavioral results showed that the old group had difficulties with attentional modulation of the right-ear advantage in the attend left condition. This is interpreted as a failure of an important aspect of attentional control; the top-down biasing of attention for selection of task-relevant stimulus. The fMRI results showed that an area in the left middle frontal gyrus was more activated in the young group compared to the old group in the attend left condition. The structural MRI data showed reduced gray matter density of the same area in the old group. Based on these converging findings, we suggest that the left middle frontal gyrus plays an important role in top-down biasing of selecting task-relevant stimuli, and to inhibit processing of task-irrelevant stimuli. To our knowledge, this is one of the first studies addressing the question on how age-related changes in attentional processing is reflected in both functional and structural differences in the brain.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1053-8119
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
912-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Brain localization of attentional control in different age groups by combining functional and structural MRI.
pubmed:affiliation
Department of Biological and Medical Psychology, University of Bergen, N-5009 Bergen, Norway. Tormod.Thomsen@psych.uib.no
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't