Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13
pubmed:dateCreated
2004-7-7
pubmed:abstractText
The TREX complex is involved in both transcription elongation and mRNA export and is recruited to nascent transcription complexes. We have examined Yra1p, Sub2p and Hpr1p recruitment to nine genes of varying lengths and transcription frequencies. All three proteins increase from the 5' to the 3' ends of the four intronless genes examined. A modified chromatin immunoprecipitation assay that includes an RNase step indicates that Sub2p is bound to nascent RNA, Yra1p is associated with both RNA and DNA, and Hpr1p is associated with DNA. Although Hpr1p is recruited similarly to both intronless and intron-containing genes, low Yra1p and Sub2p levels are present on a subset of intron-containing genes. The residual Yra1p and Sub2p recruitment is less RNA-associated, and this correlates with high levels of U1 SnRNP on these genes. These experiments support a model in which TREX is recruited via the transcription machinery and then Yra1p and Sub2p are transferred to the nascent RNA. On some intron-containing genes, retention and/or transfer of Yra1p and Sub2p to nascent RNA are inhibited.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-10198639, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-10207065, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-10547847, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-10722314, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-10775271, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-10786854, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-10952996, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-11014198, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-11018013, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-11060033, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-11118221, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-11156602, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-11156603, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-11156604, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-11158589, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-11320412, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-11390651, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-11459827, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-11463828, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-11675789, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-11675790, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-11979277, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-11991638, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-12015125, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-12049745, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-12093753, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-12176931, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-12414728, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-12414731, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-12414732, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-12417727, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-12417728, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-12477934, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-12893175, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-12897147, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-14517302, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-14527416, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-14718167, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-14731395, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-14739930, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-1701407, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-1988947, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-2005799, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-2472398, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-2655924, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-2659436, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-3422466, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-8065323, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-9214641, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-9731529, http://linkedlifedata.com/resource/pubmed/commentcorrection/15192704-9845373
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Triphosphatases, http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Fungal Proteins, http://linkedlifedata.com/resource/pubmed/chemical/HPR1 protein, S cerevisiae, http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Fungal, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/RNA Helicases, http://linkedlifedata.com/resource/pubmed/chemical/RNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/RNA-dependent ATPase, http://linkedlifedata.com/resource/pubmed/chemical/Saccharomyces cerevisiae Proteins, http://linkedlifedata.com/resource/pubmed/chemical/YRA1 protein, S cerevisiae
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0261-4189
pubmed:author
pubmed:issnType
Print
pubmed:day
7
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2620-31
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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