Source:http://linkedlifedata.com/resource/pubmed/id/15192017
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
2004-9-23
|
| pubmed:abstractText |
Bovine lactoferrin, a multifunctional glycoprotein, has been shown to strongly inhibit development of azoxymethane (AOM)-induced rat colon tumors. Little, however, is known about the inhibitory mechanisms. We have demonstrated recently that lactoferrin enhances the expression of a member of the tumor necrosis factor receptor family, Fas, in the colon mucosa during both early and late stages of carcinogenesis. Thus, Fas could be involved in bovine lactoferrin-mediated inhibition of tumor development. To investigate this possibility, we studied the influence of bovine lactoferrin on Fas-mediated apoptosis with regard to expression of Fas, activation of caspase-8 and caspase-3, and DNA fragmentation in the colon mucosa of AOM-treated rats. Western blot analysis demonstrated a >2.5-fold increase in Fas protein expression, as well as elevation of the active forms of both caspase-8 and caspase-3. Immunohistochemical analysis revealed Fas-positive cells and apoptotic cells preferentially within the proximal colon region, clearly at the site of bovine lactoferrin-mediated tumor inhibition. These results suggest that apoptosis caused by elevated expression of Fas is involved in chemoprevention by lactoferrin of colon carcinogenesis.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD95,
http://linkedlifedata.com/resource/pubmed/chemical/Azoxymethane,
http://linkedlifedata.com/resource/pubmed/chemical/Carcinogens,
http://linkedlifedata.com/resource/pubmed/chemical/Caspases,
http://linkedlifedata.com/resource/pubmed/chemical/Lactoferrin,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Tnfrsf6 protein, rat
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0143-3334
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
25
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1961-6
|
| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:15192017-Animals,
pubmed-meshheading:15192017-Antigens, CD95,
pubmed-meshheading:15192017-Apoptosis,
pubmed-meshheading:15192017-Azoxymethane,
pubmed-meshheading:15192017-Carcinogens,
pubmed-meshheading:15192017-Caspases,
pubmed-meshheading:15192017-Cattle,
pubmed-meshheading:15192017-Cell Transformation, Neoplastic,
pubmed-meshheading:15192017-Chemoprevention,
pubmed-meshheading:15192017-Colon,
pubmed-meshheading:15192017-Colonic Neoplasms,
pubmed-meshheading:15192017-Enzyme Activation,
pubmed-meshheading:15192017-Immunoenzyme Techniques,
pubmed-meshheading:15192017-Lactoferrin,
pubmed-meshheading:15192017-Male,
pubmed-meshheading:15192017-Proteins,
pubmed-meshheading:15192017-Rats,
pubmed-meshheading:15192017-Rats, Inbred F344,
pubmed-meshheading:15192017-Receptors, Tumor Necrosis Factor
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| pubmed:year |
2004
|
| pubmed:articleTitle |
Lactoferrin enhances Fas expression and apoptosis in the colon mucosa of azoxymethane-treated rats.
|
| pubmed:affiliation |
Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|