| pubmed-article:15191949 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15191949 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:15191949 | lifeskim:mentions | umls-concept:C0001675 | lld:lifeskim |
| pubmed-article:15191949 | lifeskim:mentions | umls-concept:C0262950 | lld:lifeskim |
| pubmed-article:15191949 | lifeskim:mentions | umls-concept:C0302600 | lld:lifeskim |
| pubmed-article:15191949 | lifeskim:mentions | umls-concept:C1801960 | lld:lifeskim |
| pubmed-article:15191949 | lifeskim:mentions | umls-concept:C1709634 | lld:lifeskim |
| pubmed-article:15191949 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:15191949 | pubmed:dateCreated | 2004-9-20 | lld:pubmed |
| pubmed-article:15191949 | pubmed:abstractText | Bone marrow (BM)-derived cells are thought to participate in the growth of blood vessels during postnatal vascular regeneration and tumor growth, a process previously attributed to stem and precursor cells differentiating to endothelial cells. We used multichannel laser scanning confocal microscopy of whole-mounted tissues to study angiogenesis in chimeric mice created by reconstituting C57BL mice with genetically marked syngeneic BM. We show that BM-derived endothelial cells do not significantly contribute to tumor- or cytokine-induced neoangiogenesis. Instead, BM-derived periendothelial vascular mural cells were persistently detected at sites of tumor- or vascular endothelial growth factor-induced angiogenesis. Subpopulations of these cells expressed the pericyte-specific NG2 proteoglycan, or the hematopoietic markers CD11b and CD45, but did not detectably express the smooth muscle markers smooth muscle alpha-actin or desmin. Thus, the major contribution of the BM to angiogenic processes is not endothelial, but may come from progenitors for periendothelial vascular mural and hematopoietic effector cells. | lld:pubmed |
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| pubmed-article:15191949 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15191949 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15191949 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:15191949 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15191949 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:15191949 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:15191949 | pubmed:author | pubmed-author:OzerdemUgurU | lld:pubmed |
| pubmed-article:15191949 | pubmed:author | pubmed-author:AlitaloKariK | lld:pubmed |
| pubmed-article:15191949 | pubmed:author | pubmed-author:SalvenPetriP | lld:pubmed |
| pubmed-article:15191949 | pubmed:author | pubmed-author:RajantieIiroI | lld:pubmed |
| pubmed-article:15191949 | pubmed:author | pubmed-author:IlmonenMaritt... | lld:pubmed |
| pubmed-article:15191949 | pubmed:author | pubmed-author:AlminaiteAgne... | lld:pubmed |
| pubmed-article:15191949 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15191949 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:15191949 | pubmed:volume | 104 | lld:pubmed |
| pubmed-article:15191949 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15191949 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15191949 | pubmed:pagination | 2084-6 | lld:pubmed |
| pubmed-article:15191949 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:15191949 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15191949 | pubmed:articleTitle | Adult bone marrow-derived cells recruited during angiogenesis comprise precursors for periendothelial vascular mural cells. | lld:pubmed |
| pubmed-article:15191949 | pubmed:affiliation | Institute of Biomedicine, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland. | lld:pubmed |
| pubmed-article:15191949 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15191949 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15191949 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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