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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2004-9-20
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pubmed:abstractText |
Bone marrow (BM)-derived cells are thought to participate in the growth of blood vessels during postnatal vascular regeneration and tumor growth, a process previously attributed to stem and precursor cells differentiating to endothelial cells. We used multichannel laser scanning confocal microscopy of whole-mounted tissues to study angiogenesis in chimeric mice created by reconstituting C57BL mice with genetically marked syngeneic BM. We show that BM-derived endothelial cells do not significantly contribute to tumor- or cytokine-induced neoangiogenesis. Instead, BM-derived periendothelial vascular mural cells were persistently detected at sites of tumor- or vascular endothelial growth factor-induced angiogenesis. Subpopulations of these cells expressed the pericyte-specific NG2 proteoglycan, or the hematopoietic markers CD11b and CD45, but did not detectably express the smooth muscle markers smooth muscle alpha-actin or desmin. Thus, the major contribution of the BM to angiogenic processes is not endothelial, but may come from progenitors for periendothelial vascular mural and hematopoietic effector cells.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15191949-10406801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15191949-10436164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15191949-11055974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15191949-11157668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15191949-11342585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15191949-11668599,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15191949-11689883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15191949-11749079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15191949-11891196,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15191949-12039806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15191949-12062105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15191949-12215650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15191949-12415253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15191949-12740570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15191949-12778169,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15191949-12881479,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15191949-12883993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15191949-12958072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15191949-14561699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15191949-14581410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15191949-14656934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15191949-15041800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15191949-15172976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15191949-2007619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15191949-9020076
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0006-4971
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
104
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2084-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:15191949-Animals,
pubmed-meshheading:15191949-Antigens, CD11b,
pubmed-meshheading:15191949-Antigens, CD45,
pubmed-meshheading:15191949-Blood Cells,
pubmed-meshheading:15191949-Bone Marrow,
pubmed-meshheading:15191949-Bone Marrow Cells,
pubmed-meshheading:15191949-Cell Differentiation,
pubmed-meshheading:15191949-Cell Division,
pubmed-meshheading:15191949-Cell Line, Tumor,
pubmed-meshheading:15191949-Endothelial Cells,
pubmed-meshheading:15191949-Endothelium, Vascular,
pubmed-meshheading:15191949-Immunohistochemistry,
pubmed-meshheading:15191949-Melanoma, Experimental,
pubmed-meshheading:15191949-Mice,
pubmed-meshheading:15191949-Mice, Inbred C57BL,
pubmed-meshheading:15191949-Microscopy, Confocal,
pubmed-meshheading:15191949-Myocytes, Smooth Muscle,
pubmed-meshheading:15191949-Neovascularization, Pathologic,
pubmed-meshheading:15191949-Peptides,
pubmed-meshheading:15191949-Proteoglycans,
pubmed-meshheading:15191949-Time Factors,
pubmed-meshheading:15191949-Vascular Endothelial Growth Factor A
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pubmed:year |
2004
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pubmed:articleTitle |
Adult bone marrow-derived cells recruited during angiogenesis comprise precursors for periendothelial vascular mural cells.
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pubmed:affiliation |
Institute of Biomedicine, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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