| pubmed-article:15190260 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15190260 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:15190260 | lifeskim:mentions | umls-concept:C0389003 | lld:lifeskim |
| pubmed-article:15190260 | lifeskim:mentions | umls-concept:C0368761 | lld:lifeskim |
| pubmed-article:15190260 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:15190260 | lifeskim:mentions | umls-concept:C1517806 | lld:lifeskim |
| pubmed-article:15190260 | lifeskim:mentions | umls-concept:C1414481 | lld:lifeskim |
| pubmed-article:15190260 | lifeskim:mentions | umls-concept:C0205225 | lld:lifeskim |
| pubmed-article:15190260 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:15190260 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:15190260 | pubmed:dateCreated | 2004-7-22 | lld:pubmed |
| pubmed-article:15190260 | pubmed:abstractText | Cyclooxygenase (COX)-1 or -2 and specific prostaglandin (PG) synthases catalyze the formation of various PGs. We investigated the expression and activity of COX-1 and -2 during granulocyte-oriented maturation induced by all-trans-retinoic acid (ATRA) of NB4 cells, originated from a human acute promyelocytic leukemia (APL), and in blasts from APL patients. The expression of COX isoenzymes or prostaglandin synthases was also investigated in circulating granulocytes and human bone marrow. COX-1 was expressed and enzymatically active in NB4 cells and primary blasts. COX-1 mRNA and protein were induced by ATRA. COX-1 protein increased approximately 2-3.5-fold by culture day 3 in NB4 cells and primary blasts, while basal COX-2 expression was very low and unaffected by ATRA. COX-1-dependent PGE(2) biosynthesis increased during differentiation approx. 5-fold. Indomethacin and the selective COX-1 inhibitor SC-560, but not selective COX-2 inhibition, impaired NB4 differentiation, reducing NADPH-oxidase activity, CD11b and CD11c expression. The immunohistochemistry of granulocytes and myeloid precursors in the bone marrow showed a large prevalence of COX-1 as compared to COX-2. In conclusion, COX-1 is induced during ATRA-dependent maturation and appears to contribute to myeloid differentiation both in vitro and ex vivo, and COX-1 activity may potentiate the differentiation of human APL.Leukemia (2004) 18, 1373-1379. doi:10.1038/sj.leu.2403407 Published online 10 June 2004 | lld:pubmed |
| pubmed-article:15190260 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15190260 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15190260 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15190260 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15190260 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15190260 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15190260 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15190260 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:15190260 | pubmed:issn | 0887-6924 | lld:pubmed |
| pubmed-article:15190260 | pubmed:author | pubmed-author:CiabattoniGG | lld:pubmed |
| pubmed-article:15190260 | pubmed:author | pubmed-author:MaggianoNN | lld:pubmed |
| pubmed-article:15190260 | pubmed:author | pubmed-author:RanellettiF... | lld:pubmed |
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| pubmed-article:15190260 | pubmed:author | pubmed-author:HabibAA | lld:pubmed |
| pubmed-article:15190260 | pubmed:author | pubmed-author:RoccaBB | lld:pubmed |
| pubmed-article:15190260 | pubmed:author | pubmed-author:ChomienneCC | lld:pubmed |
| pubmed-article:15190260 | pubmed:author | pubmed-author:MorosettiRR | lld:pubmed |
| pubmed-article:15190260 | pubmed:author | pubmed-author:ZassadowskiFF | lld:pubmed |
| pubmed-article:15190260 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15190260 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:15190260 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15190260 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15190260 | pubmed:pagination | 1373-9 | lld:pubmed |
| pubmed-article:15190260 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:15190260 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15190260 | pubmed:articleTitle | Cyclooxygenase-1, but not -2, is upregulated in NB4 leukemic cells and human primary promyelocytic blasts during differentiation. | lld:pubmed |
| pubmed-article:15190260 | pubmed:affiliation | Department of Internal Medicine, Catholic University School of Medicine, Rome, Italy. b.rocca@tiscali.it | lld:pubmed |
| pubmed-article:15190260 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15190260 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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