Linked Life Data

15189782

Source:http://linkedlifedata.com/resource/pubmed/id/15189782

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-3
pubmed:dateCreated
2004-6-10
pubmed:abstractText
The effects of acute hyperthyroidism on the vasorelaxing responses to isoprenaline and acetylcholine were investigated in isolated rat renal and femoral arteries. In the renal artery, isoprenaline- and acetylcholine-induced relaxations were significantly greater in hyperthyroid rats than in control rats. In the femoral artery, only the acetylcholine-induced relaxation was significantly greater in hyperthyroid rats than in control rats. In the renal artery, NG-nitro-L-arginine (L-NOARG), an inhibitor of nitric oxide (NO) synthase, reduced isoprenaline- and acetylcholine-induced relaxations in both hyperthyroid and control rats and the isoprenaline-induced relaxation was still greater in hyperthyroid rats than in control rats, but no difference in the acetylcholine-induced relaxation was seen between the two groups of rats since L-NOARG almost abolished the acetylcholine-induced relaxation. In the femoral artery, L-NOAGR reduced the isoprenaline-induced relaxation in control rats but not in hyperthyroid rats, while it almost abolished the acetylcholine-induced relaxation in both groups of rats. 17-Octadecynoic acid (17-ODYA), a cytochrome P-450 monooxygenase inhibitor, reduced the isoprenaline-induced relaxation in renal and femoral arteries from hyperthyroid and control rats, but it did not change the acetylcholine-induced relaxation in both arteries. These results indicate that acute hyperthyroidism significantly enhances beta-adrenoceptor-mediated relaxation of the renal artery and muscarinic receptor-mediated relaxation of both renal and femoral arteries, suggesting that these effects may be due to an alteration in the NO and cytochrome P-450 systems of the artery.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0014-2999
pubmed:author
pubmed:copyrightInfo
Copyright 2004 Elsevier B.V.
pubmed:issnType
Print
pubmed:day
16
pubmed:volume
493
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
191-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:15189782-Acetylcholine, pubmed-meshheading:15189782-Acute Disease, pubmed-meshheading:15189782-Animals, pubmed-meshheading:15189782-Cyclooxygenase Inhibitors, pubmed-meshheading:15189782-Fatty Acids, Unsaturated, pubmed-meshheading:15189782-Femoral Artery, pubmed-meshheading:15189782-Heart Rate, pubmed-meshheading:15189782-Hyperthyroidism, pubmed-meshheading:15189782-Indomethacin, pubmed-meshheading:15189782-Isoproterenol, pubmed-meshheading:15189782-Japan, pubmed-meshheading:15189782-Male, pubmed-meshheading:15189782-Muscle, Smooth, Vascular, pubmed-meshheading:15189782-Nitroarginine, pubmed-meshheading:15189782-Nitroprusside, pubmed-meshheading:15189782-Organ Size, pubmed-meshheading:15189782-Rats, pubmed-meshheading:15189782-Rats, Wistar, pubmed-meshheading:15189782-Receptors, Adrenergic, pubmed-meshheading:15189782-Receptors, Muscarinic, pubmed-meshheading:15189782-Renal Artery, pubmed-meshheading:15189782-Thyroxine, pubmed-meshheading:15189782-Vasodilation
pubmed:year
2004
pubmed:articleTitle
Acute hyperthyroidism alters adrenoceptor- and muscarinic receptor-mediated responses in isolated rat renal and femoral arteries.
pubmed:affiliation
Second Department of Physiology, School of Medicine, Showa University, Hatanodai 1-5-8, Shinagawa, Tokyo, 142-8555, Japan.
pubmed:publicationType
Journal Article, Comparative Study