|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2004-6-10
|
|
pubmed:abstractText |
NKG2D is an activating receptor on CD8(+) T cells and NK cells that has been implicated in immunity against tumors and microbial pathogens. Here we show that RAE-1 is present in prediabetic pancreas islets of NOD mice and that autoreactive CD8(+) T cells infiltrating the pancreas express NKG2D. Treatment with a nondepleting anti-NKG2D monoclonal antibody (mAb) during the prediabetic stage completely prevented disease by impairing the expansion and function of autoreactive CD8(+) T cells. These findings demonstrate that NKG2D is essential for disease progression and suggest a new therapeutic target for autoimmune type I diabetes.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Klrk1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/NK Cell Lectin-Like Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Raet1a protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Natural Killer Cell
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
1074-7613
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
20
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
757-67
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:15189740-Adoptive Transfer,
pubmed-meshheading:15189740-Animals,
pubmed-meshheading:15189740-Antibodies,
pubmed-meshheading:15189740-CD8-Positive T-Lymphocytes,
pubmed-meshheading:15189740-Cell Division,
pubmed-meshheading:15189740-Diabetes Mellitus, Experimental,
pubmed-meshheading:15189740-Diabetes Mellitus, Type 1,
pubmed-meshheading:15189740-Flow Cytometry,
pubmed-meshheading:15189740-Islets of Langerhans,
pubmed-meshheading:15189740-Membrane Proteins,
pubmed-meshheading:15189740-Mice,
pubmed-meshheading:15189740-Mice, Inbred NOD,
pubmed-meshheading:15189740-Mice, SCID,
pubmed-meshheading:15189740-Mice, Transgenic,
pubmed-meshheading:15189740-NK Cell Lectin-Like Receptor Subfamily K,
pubmed-meshheading:15189740-RNA, Messenger,
pubmed-meshheading:15189740-Receptors, Immunologic,
pubmed-meshheading:15189740-Receptors, Natural Killer Cell
|
|
pubmed:year |
2004
|
|
pubmed:articleTitle |
NKG2D blockade prevents autoimmune diabetes in NOD mice.
|
|
pubmed:affiliation |
Department of Microbiology and Immunology and The Cancer Research Institute, HSE 1001, Box 0414, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
