Linked Life Data

15189679

Source:http://linkedlifedata.com/resource/pubmed/id/15189679

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2004-6-10
pubmed:abstractText
We determined tissue distribution of diltiazem after it was used to treat hypertension in two cases. The postmortem interval was 16 h in both cases. Diltiazem was isolated using liquid-liquid extraction, and it was identified and quantitated using gas chromatography-mass spectrometry (GC-MS) and GC, respectively. In one case, diltiazem concentrations in the lungs and pulmonary vessel blood were 62-82 and 27-30 times higher than right femoral blood, respectively. Although blood was not obtained from the left cardiac chambers, aortic blood showed a 10-times higher level of diltiazem than right femoral venous blood. Diltiazem concentration in blood in the right cardiac chambers was 3.6 times higher than that in right femoral venous blood. In another case, diltiazem concentrations in the lungs were 7.4-7.6 times higher than right femoral venous blood. Blood in the pulmonary arteries, pulmonary veins, left cardiac chambers, and aorta showed 2.0-3.1 times higher levels of diltiazem than right femoral venous blood. Blood in the right cardiac chambers displayed only 1.3 times higher level of diltiazem than right femoral venous blood. Our results strongly suggest that diltiazem accumulated in the lungs and was rapidly redistributed into pulmonary venous blood and then into the left cardiac chambers.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0146-4760
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
269-71
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Redistribution of diltiazem in the early postmortem period.
pubmed:affiliation
Department of Legal Medicine, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi 783-8505, Japan.
pubmed:publicationType
Journal Article, Case Reports