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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
17
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pubmed:dateCreated |
1992-10-7
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pubmed:databankReference |
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pubmed:abstractText |
Lymphocytes express integrin receptors, termed lymphocyte Peyer's patch high endothelial venule (HEV) adhesion molecules (LPAMs), that mediate their organ-specific adhesion to specialized HEVs found in mucosal lymphoid organs (Peyer's patches). LPAM-1 consists of a murine integrin alpha 4 noncovalently associated with integrin beta p. Here, we describe the cloning and expression of a mouse cDNA encoding beta p, which is an 806-amino acid transmembrane glycoprotein. The genomic Southern blot analysis indicates that beta p is the murine homologue of human beta 7. The function of alpha 4 beta 7 as a Peyer's patch-specific adhesion molecule was tested directly by expression of the murine beta 7 cDNA in an alpha 4+ beta 7-B-cell line or coexpression of the alpha 4 and beta 7 cDNAs in an alpha 4-beta 7-T-cell line. The transfected cells exhibited a new Peyer's patch-specific adhesive phenotype that could be specifically blocked by monoclonal antibodies against alpha 4 and beta 7. Moreover, an anti-beta 7 monoclonal antibody specifically blocked binding of normal lymphocytes to Peyer's patch HEV but did not inhibit their binding to peripheral lymph node HEVs, indicating that beta 7 is a unique component of the Peyer's patch-specific homing receptor.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1518854-1370869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1518854-1372909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1518854-1373725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1518854-14114163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1518854-1555235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1518854-1673981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1518854-1698283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1518854-1753094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1518854-1840602,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1518854-1915560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1518854-2040616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1518854-2083230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1518854-2139716,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1518854-2419440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1518854-2426181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1518854-2460470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1518854-2463092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1518854-2631796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1518854-2670559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1518854-2831375,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1518854-3004743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1518854-3340147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1518854-3714490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1518854-956727
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8254-8
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1518854-Amino Acid Sequence,
pubmed-meshheading:1518854-Animals,
pubmed-meshheading:1518854-Antibodies, Monoclonal,
pubmed-meshheading:1518854-Base Sequence,
pubmed-meshheading:1518854-Blotting, Western,
pubmed-meshheading:1518854-Cell Adhesion,
pubmed-meshheading:1518854-Cloning, Molecular,
pubmed-meshheading:1518854-DNA,
pubmed-meshheading:1518854-Endothelium, Vascular,
pubmed-meshheading:1518854-Fluorescent Antibody Technique,
pubmed-meshheading:1518854-Gene Expression,
pubmed-meshheading:1518854-Integrins,
pubmed-meshheading:1518854-Mice,
pubmed-meshheading:1518854-Molecular Sequence Data,
pubmed-meshheading:1518854-Peyer's Patches,
pubmed-meshheading:1518854-RNA, Messenger,
pubmed-meshheading:1518854-Receptors, Lymphocyte Homing
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pubmed:year |
1992
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pubmed:articleTitle |
Cloning and expression of mouse integrin beta p(beta 7): a functional role in Peyer's patch-specific lymphocyte homing.
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pubmed:affiliation |
Howard Hughes Medical Institute, Department of Pathology, Stanford University School of Medicine, CA 94305.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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