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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2004-6-9
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pubmed:abstractText |
Dnase1-deficient mice with the 129 x C57BL/6 genetic background develop symptoms of systemic lupus erythematosus, such as high titers of antinuclear autoantibodies directed against nucleosomes. In this study we analyzed a potential molecular pathomechanism leading to this autoimmunity, by exploring the influence of extracellular Dnase1 present in serum on the breakdown of chromatin in necrotic cells in vitro.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0004-3591
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1873-83
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15188364-Adenocarcinoma,
pubmed-meshheading:15188364-Animals,
pubmed-meshheading:15188364-Antibodies, Antinuclear,
pubmed-meshheading:15188364-Autoimmunity,
pubmed-meshheading:15188364-Breast Neoplasms,
pubmed-meshheading:15188364-Chromatin,
pubmed-meshheading:15188364-DNA,
pubmed-meshheading:15188364-Deoxyribonuclease I,
pubmed-meshheading:15188364-Extracellular Space,
pubmed-meshheading:15188364-HL-60 Cells,
pubmed-meshheading:15188364-Histones,
pubmed-meshheading:15188364-Humans,
pubmed-meshheading:15188364-Mice,
pubmed-meshheading:15188364-Mice, Inbred C57BL,
pubmed-meshheading:15188364-Mice, Mutant Strains,
pubmed-meshheading:15188364-NIH 3T3 Cells,
pubmed-meshheading:15188364-Necrosis,
pubmed-meshheading:15188364-Plasminogen
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pubmed:year |
2004
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pubmed:articleTitle |
Chromatin breakdown during necrosis by serum Dnase1 and the plasminogen system.
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pubmed:affiliation |
Abteilung für Anatomie und Embryologie, Ruhr-Universität Bochum, Bochum, Germany. markus.napirei@ruhr-unibochem.de
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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