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pubmed:abstractText |
After hemorrhagic shock, macrophages are less responsive to lipopolysaccharide (LPS) regarding cytokine production and receptor expression. However, mechanisms responsible for this are poorly understood. Suppressors of cytokine signaling (SOCS) proteins have been found to play a prominent role in LPS tolerance and cytokine desensitization in macrophages. Therefore, the purpose of this study was to determine whether hemorrhagic shock induced SOCS expression.
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pubmed:affiliation |
Department of Surgery, Division of Surgical Research, Rhode Island Hospital and Brown University Medical School, Providence, Rhode Island 02903, USA.
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